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. Author manuscript; available in PMC: 2026 Jun 19.
Published in final edited form as: DNA Repair (Amst). 2025 Oct 23;155:103908. doi: 10.1016/j.dnarep.2025.103908

Fig. 5.

Fig. 5.

Structural basis of AP-site recognition in the nucleosome by APE1. (A) Cryo-EM model of the APE1-AP-NCP–6 complex (PDB: 7U50). (B) Focused views of the nucleosomal DNA from SHL–5.5 to the nucleosome entry/exit site in the AP-NCP–6 (left) and APE1-AP-NCP–6 complex (right). The local deformations in the nucleosomal DNA induced by APE1 during AP-site recognition are labeled.