Table 1.
SARS-CoV-2 spike-based vaccines.
| Vaccine | Manufacturer | Type | Dose | 2024-2025 strain | Major components | Omicron update |
|---|---|---|---|---|---|---|
| Comirnarty | Pfizer-BioNTech | mRNA–LNP | 30 μg in 0.3 ml | Omicron KP.2 | mRNA expressing stabilized recombinant Spike protein (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate) PEG2000-DMG Cholesterol DSPC* |
Yes |
| Spikevax | Moderna | mRNA–LNP | 50 μg in 0.5 ml | Omicron KP.2 | mRNA expressing stabilized recombinant Spike protein SM-102 PEG2000- ditetradecylacetamide Cholesterol DSPC |
Yes |
| Nuvaxovid or Covovax | Novavax | Subunit | ~135 μg in 0.5 ml | Omicron JN.1 |
5 μg stabilized recombinant Spike protein in a QuillA saponin adjuvant | Yes |
| JCovden | Janssen | Viral vector | 8.9 infectious units in 0.5 ml | Discontinued May 2023 |
Ad26 expressing S protein | No |
| Vaxzevria or Covishield |
Oxford/AstraZeneca | Viral vector | 5 x 1010 infectious particles in 0.5 ml | Discontinued May 2024 |
Chimpanzee adenovirus vector ChAdOx1 expressing S protein |
No |
| Convidecia | Cansino | Viral vector | 5 x 1010 infectious particles in 0.5 ml | Not known | Ad5 expressing S protein | No |
| Sputnik V | Gamaleya Research Institute | Viral vector | 5 x 1010 infectious particles each of Ad5 and Ad26 in 1 ml | Not known | Mixture of Ad5 and Ad26 expressing S protein | No |
| Coronavac | Sinovac | Inactivated virus | 600 SU of inactivated SARS-CoV-2 in 0.5 ml | Discontinued January 2024 | Whole inactivated virus | No |
| BBIBP-CorV | Sinopharm-Beijing | Inactivated virus |
4 μg of inactivated SARS-CoV-2 in 0.5 ml | Discontinued | β-propiolactone inactivated 19nCoV-CDC-Tan-HB02 in aluminum hydroxide | No |
| Covaxin | Bharat Biotech | Inactivated virus | 6 μg of inactivated SARS-CoV-2 in 0.5 ml | Suspended April 2022 | Whole inactivated | No |
| VidPrevtyn Beta | Sanofi–GSK | Subunit | 5 μg of SARS-CoV-2 S protein in 0.5 ml | Discontinued March 202 | 5 ug S protein subunit vaccine based on Beta (B.1.351) strain | No |
*
DSPC, distearoylphosphatidylcholine; LNP, lipid nanoparticle; SM-102, ionizable amino lipid