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. Author manuscript; available in PMC: 2026 Feb 28.
Published in final edited form as: Nature. 2025 Sep;645(8080):544. doi: 10.1038/s41586-025-09538-2

Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB1

Tian Hua, Kiran Vemuri, Spyros P Nikas, Robert B Laprairie, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho, Gye Won Han, Kang Ding, Xuanxuan Li, Haiguang Liu, Michael A Hanson, Suwen Zhao, Laura M Bohn, Alexandros Makriyannis, Raymond C Stevens, Zhi-Jie Liu
PMCID: PMC12947850  NIHMSID: NIHMS2141498  PMID: 40866714

The authors are retracting this article to correct the scientific literature owing to issues noticed with cell-based cAMP accumulation data of mutants of the CB1 receptor in response to CB1 agonists. These data were presented in Fig. 1d, Fig. 3c, Extended Data Fig. 4 and Extended Data Table 2. The authors have repeated these experiments independently and the new data, which do not alter the conclusions of the study, are presented in a revised manuscript, which has now been published after peer review1.

All authors agree with the retraction.

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