TABLE 1.
Baseline characteristics (four-color flow analysis)
| Parameter | Responders (n = 41) | Controllers (n = 32) | PCAT (n = 31) | Noncontrollers (n = 19) |
|---|---|---|---|---|
| Age (yrs) | 50 (44-54) | 43 (38-50) | 47 (43-52) | 43 (38-46) |
| Plasma HIV RNA (log10 copies/ml) | 1.88 (1.88-1.88) | 2.23 (1.88-3.16) | 3.49 (2.66-3.77) | 4.53 (4.21-5.39) |
| CD4+ cell count (cells/mm3) | 466 (297-660) | 582 (450-852) | 281 (231-436) | 223 (138-330) |
| CD8+ cell count (cells/mm3) | 1,031 (655-1,404) | 974 (689-1,091) | 1,119 (755-1,831) | 955 (629-2,195) |
| CD4+ T-cell nadir (cells/mm3) | 95 (41-172) | 69 (20-199) | ||
| Duration of HIV infection (yrs) | 15 (11-17) | 15 (12-17) | 16 (13-19) | 14 (10-16) |
| Abacavir IC50a (fold change) | 5.0 (3.1-7.1) | |||
| Protease inhibitor IC50 (fold change) | 54 (17.3-98) | |||
| Replicative capacity (% of reference) | 43 (20-74) |
a
IC50, 50% inhibitory concentration.