FIG. 2.
Proportion of CD4+ and CD8+ T cells secreting IFN-γ and/or IL-2 in response to HIV-1 Gag peptide pools. (A) The percentage of cytokine-secreting CD4+ T cells (CD3+ CD4+) in response to Gag peptide pools is shown for four patient groups. * signifies a P value of <0.05 for any cytokine profile comparing the reference group to noncontrollers. (B) The percentage of cytokine-secreting CD8+ T cells (CD3+ CD4−) in response to Gag peptide pools is shown for four patient groups. * signifies a P value of <0.05 for any cytokine profile comparing the reference group to noncontrollers. (C) The percentage of cytokine-secreting CD4+ and CD8+ T cells in antiretroviral-untreated patients with undetectable HIV RNA levels (“elite suppressors”) and antiretroviral-treated subjects with undetectable HIV RNA levels. All differences between subject groups were significant (P < 0.006 for each pairwise comparison). There was no difference between the groups in terms of IFN-γ− IL-2+ CD4+ or CD8+ T cells (data not shown).