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Role of anti-inflammatory cytokines in the humoral response to R36A . IL-4−/−, IL-10−/−, and control mice were immunized i.p. with R36A (2 × 108 CFU/mouse). Sera were collected on day 7 (primary anti-PC), day 14 (primary anti-PspA), and day 21 after boosting with R36A (secondary anti-PspA). Values represent the arithmetic means ± SEM of seven mice per group. *, P < 0.05. Data are representative of two similar experiments.
