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A: IVA plasma concentration vs time profile following the IV administration of free IVA to mice at a dose of 5 mg/kg (n=3, data points are means ± SD). B: Predicted and observed IVA plasma concentration vs time profile following the oral administration of either IVA/HP-β-CD (1:2) complexes or Kalydeco tablets at a dose of 25 mg/kg (n=1–3, data points are means ± SD).
