Retraction Notice to “Aberrant CD8⁺ T-Cell Responses and Memory Differentiation upon Viral Infection of an Ataxia-Telangiectasia Mouse Model Driven by Hyper-Activated Akt and mTORC1 Signaling” [Am J Pathol 178 (2011) 2740–2751]

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).

This article has been retracted at the request of the authors and the Editor-in-Chief.

Western blots (Figures 3C and 4A) appear to have been inappropriately manipulated (including gel-slice image duplications and reorientations that compromise the data). The main conclusions from these data were that ATM^–/– CD8⁺ T cells in vitro have hyper-activated AMPK and Akt signaling (after TCR and IL-15 stimulation) and hyper-activated mTORC1 signaling (after TCR activation alone). The authors acknowledge that the western data manipulations compromise the conclusions reached about specific signaling pathway activation/perturbations in the WT and ATM^–/– T cells in vitro.