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Fig. 8. VEGFR-3 mediates endothelial cell migration. The migration of HMVECs in the presence of different VEGFs in a Boyden chamber assay. VEGF-C156S-, but not VEGF-stimulated migration was blocked by pre-incubating VEGF-C156S with a 10-fold molar excess of soluble VEGFR-3 (light grey bars). Data represent mean values from three independent experiments (mean ± SD). The growth factor concentrations used are: VEGF, 10 ng/ml; VEGF-C, 500 ng/ml; VEGF-D, 500 ng/ml; and VEGF-C156S, 3 µg/ml.
