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. 2005 Oct;43(10):5208–5213. doi: 10.1128/JCM.43.10.5208-5213.2005

TABLE 2.

Interpretive agreement between results of voriconazole disk diffusion tests and of standard 48-h BMDa

Organism (no. tested) Test methodc % of results in each categoryb
% Agreementd % Errors
S SDD R VME ME M
C. albicans (1,630) Ref.-MIC 100.0 0.0 0.0
Ref.-disk 99.8 0.1 0.1 99.8 0.0 0.1 0.1
Part.-disk 98.2 0.1 1.7 98.2 0.0 1.7 0.1
C. glabrata (402) Ref.-MIC 96.3 1.5 2.2
Ref.-disk 96.0 0.3 3.7 97.3 0.5 0.5 1.7
Part.-disk 84.1 7.2 8.7 84.8 0.5 6.0 8.7
C. parapsilosis (399) Ref.-MIC 99.5 0.25 0.25
Ref.-disk 99.0 0.8 0.2 99.0 0.0 0.0 1.0
Part.-disk 91.7 3.8 4.5 92.0 0.0 4.0 4.0
C. tropicalis (325) Ref.-MIC 99.7 0.0 0.3
Ref.-disk 98.2 0.9 0.9 97.9 0.3 0.9 0.9
Part.-disk 85.8 5.9 8.3 85.5 0.3 8.3 5.9
C. krusei (85) Ref.-MIC 100.0 0.0 0.0
Ref.-disk 98.8 1.2 0.0 98.8 0.0 0.0 1.2
Part.-disk 89.4 5.9 4.7 89.4 0.0 4.7 5.9
All Candida species (2,934) Ref.-MIC 99.4 0.2 0.4
Ref.-disk 98.9 0.4 0.7 99.0 0.1 0.2 0.7
Part.-disk 94.0 2.1 3.9 94.1 0.1 3.4 2.4
a

Voriconazole disk diffusion testing was performed according to CLSI method M44-A, and voriconazole BMD MIC testing was performed according to CLSI method M27-A2.

b

Voriconazole susceptibility categories are as follows: S, susceptible (MIC of ≤1 μg/ml, zone diameter of ≥17 mm); SDD, susceptible dose dependent (MIC of 2 μg/ml, zone diameter of 14 to 16 mm); R, resistant (MIC of ≥4 μg/ml, zone diameter of ≤13 mm).

c

Ref.-MIC, MIC testing performed by ARTEMIS reference laboratory; Ref.-disk, disk testing performed by ARTEMIS reference laboratory; Part.-disk, disk testing performed by ARTEMIS participants.

d

Percent categorical agreement between disk diffusion and MIC test results.