TABLE 2.
Resistance profile of RSV polymerase inhibitors
| Compound | Polymerase IC50 (μM)a | Antiviral EC50 (μM)b | Minigenome EC50 (μM)c |
|---|---|---|---|
| C | 6.2 (7) | 2.0 (8) | 3.6 (8) |
| D | 1.1 (12) | 0.40 (19) | 0.30 (9) |
a
RSV polymerase poly-A capture assays were performed with RSV RNP isolated from cells infected with RSV Long Cr-1.
b
Antiviral activity against RSV Cr-1 was measured by ELISA.
c
Activity in the minigenome assay was measured using the mutated pcDNA-LI1381S plasmid. Values in parenthesis indicate the n-fold increase compared to wild-type (mutant/WT).