Table 5.
Power Comparisons of the Three Tests (QSAT, TDTMK, and TDTVC) in Simulations based on Empirical Population Genetics Data, under the Random Sampling Scheme[Note]
|
Power |
||||||||||||||
|
P=.05 |
P=.01 |
|||||||||||||
| TDTMK |
TDTVC |
TDTMK |
TDTVC |
|||||||||||
| Status of High-RiskAllele, Trait Distribution,and Model | QSAT | n/3 | 2n/3 | n | n/3 | 2n/3 | n | QSAT | n/3 | 2n/3 | n | n/3 | 2n/3 | n |
| Fixed: | ||||||||||||||
| Normal: | ||||||||||||||
| Dominant | .98 | .53 | .77 | .86 | .31 | .55 | .64 | .97 | .31 | .61 | .77 | .16 | .37 | .50 |
| Additive | .98 | .44 | .74 | .87 | .30 | .54 | .65 | .96 | .20 | .55 | .74 | .13 | .39 | .50 |
| Recessive | .91 | .32 | .55 | .65 | .23 | .43 | .53 | .85 | .14 | .35 | .50 | .10 | .29 | .37 |
| Log-normal: | ||||||||||||||
| Dominant | .97 | .60 | .78 | .86 | .32 | .54 | .64 | .94 | .43 | .67 | .79 | .18 | .38 | .48 |
| Additive | .96 | .61 | .79 | .90 | .36 | .57 | .66 | .90 | .39 | .64 | .80 | .21 | .40 | .53 |
| Recessive | .90 | .40 | .57 | .66 | .26 | .47 | .54 | .83 | .21 | .42 | .53 | .13 | .32 | .43 |
| Random: | ||||||||||||||
| Normal: | ||||||||||||||
| Dominant | .90 | .31 | .43 | .54 | .20 | .38 | .48 | .81 | .17 | .27 | .39 | .09 | .22 | .34 |
| Additive | .91 | .48 | .65 | .80 | .29 | .53 | .64 | .82 | .26 | .44 | .64 | .16 | .34 | .50 |
| Recessive | .96 | .60 | .75 | .84 | .33 | .55 | .64 | .93 | .41 | .61 | .75 | .19 | .38 | .48 |
| Log-normal: | ||||||||||||||
| Dominant | .86 | .30 | .47 | .55 | .19 | .43 | .48 | .78 | .20 | .32 | .42 | .14 | .28 | .35 |
| Additive | .88 | .46 | .72 | .80 | .25 | .50 | .63 | .80 | .24 | .54 | .69 | .15 | .37 | .48 |
| Recessive | .93 | .58 | .77 | .85 | .30 | .55 | .64 | .90 | .39 | .64 | .77 | .17 | .40 | .50 |
Note.— Sample size is n=150 for the QSAT and 50, 100, and 150 for TDT tests.