Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1982;328:351–360. doi: 10.1113/jphysiol.1982.sp014268

Noradrenaline receptors on the rat basilar artery.

G D Hirst, T O Neild, G D Silverberg
PMCID: PMC1225662  PMID: 6127405

Abstract

1. Intracellular recordings were obtained from the arterial smooth muscle cells of rat basilar artery during perivascular nerve stimulation and during the application of adrenoceptor agonists and antagonists. 2. Perivascular nerve stimulation evoked excitatory junction potentials. Increased stimulation resulted in action potentials which were associated with arterial constriction. 3. Bath-applied noradrenaline did not cause constriction but at high concentrations caused membrane depolarization. The depolarization caused by a given dose of noradrenaline was larger in the presence of cocaine. 4. Neither the depolarizations obtained by nerve stimulation nor those obtained by bath-applied noradrenaline were blocked by adrenoceptor blocking agents. 5. Unlike alpha-receptors, the receptors on the rat basilar artery were activated equally well by dopamine, adrenaline, and both optical isomers of noradrenaline. 6. Excitatory junction potentials could be obtained in the presence of high bath concentrations of noradrenaline.

Full text

PDF
351

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell C. Transmission from vasoconstrictor and vasodilator nerves to single smooth muscle cells of the guinea-pig uterine artery. J Physiol. 1969 Dec;205(3):695–708. doi: 10.1113/jphysiol.1969.sp008991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bell C., Vogt M. Release of endogenous noradrenaline from an isolated muscular artery. Release of endogenous noradrenaline from an isolated muscular artery. J Physiol. 1971 Jun;215(2):509–520. doi: 10.1113/jphysiol.1971.sp009482. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Casteels R., Kitamura K., Kuriyama H., Suzuki H. Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol. 1977 Sep;271(1):63–79. doi: 10.1113/jphysiol.1977.sp011990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Davey M. J. Aspects of the pharmacology of prazosin. Med J Aust. 1980 Jul 26;2 (Suppl 1):4–8. [PubMed] [Google Scholar]
  5. Duckles S. P., Bevan J. A. Pharmacological characterization of adrenergic receptors of a rabbit cerebral artery in vitro. J Pharmacol Exp Ther. 1976 May;197(2):371–378. [PubMed] [Google Scholar]
  6. Furness J. B., Costa M., Wilson A. J. Water-stable fluorophores, produced by reaction with aldehyde solutions, for the histochemical localization of catechol- and indolethylamines. Histochemistry. 1977 May 20;52(2):159–170. doi: 10.1007/BF00492292. [DOI] [PubMed] [Google Scholar]
  7. Hirst G. D., Neild T. O. An analysis of excitatory junctional potentials recorded from arterioles. J Physiol. 1978 Jul;280:87–104. doi: 10.1113/jphysiol.1978.sp012374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hirst G. D., Neild T. O. Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Nature. 1980 Feb 21;283(5749):767–768. doi: 10.1038/283767a0. [DOI] [PubMed] [Google Scholar]
  9. Hirst G. D., Neild T. O. Localization of specialized noradrenaline receptors at neuromuscular junctions on arterioles of the guinea-pig. J Physiol. 1981;313:343–350. doi: 10.1113/jphysiol.1981.sp013669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hirst G. D., Neild T. O. Some properties of spontaneous excitatory junction potentials recorded from arterioles of guinea-pigs. J Physiol. 1980 Jun;303:43–60. doi: 10.1113/jphysiol.1980.sp013269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hirst G. D. Neuromuscular transmission in arterioles of guinea-pig submucosa. J Physiol. 1977 Dec;273(1):263–275. doi: 10.1113/jphysiol.1977.sp012093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Holman M. E., Surprenant A. M. Some properties of the excitatory junction potentials recorded from saphenous arteries of rabbits. J Physiol. 1979 Feb;287:337–351. doi: 10.1113/jphysiol.1979.sp012663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Holman M. E., Surprenant A. An electrophysiological analysis of the effects of noradrenaline and alpha-receptor antagonists on neuromuscular transmission in mammalian muscular arteries. Br J Pharmacol. 1980;71(2):651–661. doi: 10.1111/j.1476-5381.1980.tb10986.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Iwayama T., Furness J. B., Burnstock G. Dual adrenergic and cholinergic innervation of the cerebral arteries of the rat. An ultrastructural study. Circ Res. 1970 May;26(5):635–646. doi: 10.1161/01.res.26.5.635. [DOI] [PubMed] [Google Scholar]
  15. Silverberg G. D., Ross G., Corbin S. D., New W. Time course of serotonin-induced vasoconstriction. Neurosurgery. 1979 Jun;4(6):539–542. doi: 10.1227/00006123-197906000-00009. [DOI] [PubMed] [Google Scholar]
  16. Somlyo A. P., Somlyo A. V. Vascular smooth muscle. I. Normal structure, pathology, biochemistry, and biophysics. Pharmacol Rev. 1968 Dec;20(4):197–272. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES