Table 5.
Safety analysis (Numbers needed to Harm)
| Outcome | Number of Studies | Numbers Needed to Harm (95% Confidence Interval) |
|---|---|---|
| Gastrointestinal | ||
| Gastrointestinal side effects | 8 | NNTH 8 (NNTH 5 to NNTH 21) |
| Nausea | 12 | NNTH 8 (NNTH 5 to NNTH 14) |
| Vomiting | 9 | NNTH 12 (NNTH 7 to NNTH 25) |
| Diarrhea | 12 | NNTH 20 (NNTH 11 to NNTH 53) |
| Constipation | 4 | NNTH 21 (NNTH 12 to NNTH 46) |
| Endocrinology | ||
| Minor hypoglycaemic events | 2 | NNTH 36 (NNTH 18 to NNTH 113) |
| Symptomatic hypoglycaemic events | 3 | NNTH 22 (NNTH 10 to NNTH 113) |
| Severe symptomatic hypoglycaemic events | 7 | NNTH 2307 (NNTH 82 to ∞ to NNTB 125) |
| Neurology | ||
| Dizziness | 4 | NNTH 60 (NNTH 27 to NNTH 848) |
| Headache | 6 | NNTH 152 (NNTH 45 to ∞ to NNTB 162) |
| Hepatobiliary | ||
| Overall pancreatitis | s5 | NNTH 1743 (NNTH 368 to ∞ to NNTB 1612) |
| Acute Pancreatitis | 5 | NNTH 2550 (NNTH 523 to ∞ to NNTB 436) |
| Cholelithiasis | 2 | NNTH 459 (NNTH 132 ∞ to NNTB 670) |
| Rheumatology | ||
| Severe allergic reactions | 3 | NNTH 425 (NNTH 42 to ∞ to NNTB 105) |
| Hypersensitivity syndrome or symptoms | 2 | NNTB 638 (NNTB 589 to NNTB 695) |
When the numbers needed to harm crosses infinity, it means that for the current outcome, no clear harm for the outcome can be seen statistically
Legend: NNTH, Numbers needed to harm; TEAE, Treatment-emergent adverse events; ∞, Infinity;