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Replication profiles of wild-type and mutant viruses. Cell supernatants were analyzed for RT content at the indicated times as previously described (38). Like HIV-1K34A, cells infected with the negative-control CTD-deletion strain HIV-11-212 (40) failed to yield evidence of virus spread over 2 months of observation. Similar results were obtained following an independent set of infections. WT, wild type; dpi, days postinfection.
