Fig. 6. RNA-sequencing of Grp-/- mice following recall in SEFL.
A Expression differences in dopamine signaling-related genes in RNA-seq data recapitulate patterns observed in qPCR datasets. Comparisons of TPM (transcripts per million) based on 4 replicates and (*) indicates significant differences based on p-values < 0.05 based on a t-test. B Results of differential expression for the comparison indicated in the panel headers. Shades of blue and red indicate up and downregulated genes with a q-value ≤ 0.05, respectively. To aid in visualization, darker shades indicate points with q-values larger than shown and triangular points indicate fold-changes larger than shown, see supplemental data for complete results. The number of up (blue) and downregulated (red) genes is shown at the bottom of each panel. C The top 5 GO biological process categories with the smallest set size for each comparison from the list of significant GO categories. The comparison column and color of a row indicate which set of genes were used to find a GO category. Categories with smaller set sizes are shown to increase the specificity of the categories.