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. 1988 Jul;119(3):687–691. doi: 10.1093/genetics/119.3.687

Chromosomal Location of the Regulator of Mouse α-Fetoprotein, Afr-1

E P Blankenhorn 1, R Duncan 1, K Huppi 1, M Potter 1
PMCID: PMC1203453  PMID: 2456965

Abstract

Afr-1 is a gene whose product contributes to the adult regulation of mouse α-fetoprotein (AFP). In Afr-1(b/b) homozygotes, the adult serum levels of AFP are 10- to 20-fold higher than in Afr-1(a/a) or Afr-1(a/b) mice. The studies reported here were performed to map the Afr-1 gene. Our results show that Afr-1 resides on mouse chromosome 15, approximately 25 cM from Gdc-1. Afr-1 appears to be located in close proximity to the mouse c-myc oncogene. These results are discussed with respect to the susceptibility or resistance of different BALB/c sublines (which are either Afr-1(a) or Afr-1(b), respectively) to pristane-induced plasmacytomas.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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