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. 2025 Apr 22;10(8):e189732. doi: 10.1172/jci.insight.189732

Figure 2. Apremilast decreases voluntary 2–bottle choice (2-BC) alcohol drinking across strain and sex.

Figure 2

(A–H) Effects of apremilast (10 or 20 mg/kg) in the 2-BC drinking procedure (10% v/v alcohol) in Wistar (A–D) and msP (E–H) rats (n = 8–17 rats per group). (A) Wistar male alcohol intake, F2,33 = 3.61, P = 0.03. (B) Wistar female alcohol intake, F2,50 = 15.58, P < 0.0001. (C) Wistar male alcohol preference, F2,33 = 0.44, P = 0.64. (D) Wistar female alcohol preference: F2,50 = 6.74, P = 0.002. (E) msP male alcohol intake, F2,27 = 4.81, P = 0.02. (F) msP female alcohol intake, F2,21 = 4.05, P = 0.032. (G) msP male alcohol preference, F2,27 = 4.44, P = 0.020. (H) msP female alcohol preference, F2,21 = 1.29, P = 0.29. Results are expressed as mean ± SEM and analyzed as 1-way ANOVA followed by Dunnett’s multiple-comparison post hoc test. Significant difference relative to vehicle controls is denoted by *P < 0.05, **P < 0.01, *** P < 0.001, and ****P < 0.0001.