Table 4.
mtDNA alterations in human brain tumors compared to matched tissue controls
| Type of tumor | Number of tumors | Number of tumors with mtDNA somatic mutationsa | Number of somatic mutations causing amino acid substitutionsc | Region of mutation | Reference |
| Neurofibroma | 37 | 23/37 | NAd | D-loop | Kurtz et al. 2004 |
| Glioma | 53 | 20/53 | NA | HVRII | Vega et al. 2004 |
| Meningioma | 11 | 5/11 | NA | ||
| Schwannoma | 5 | 1/5 | NA | ||
| Medulloblastoma | 15 | 6/15 | 2/18 | D-loop, Asp tRNA, COXI, CoxII, Thr tRNA, ND4 | Wong et al. 2003 |
| Gliomatosis cerebri | 6 | 2/6 | NA | HVRII | Kirches et al. 2003 |
| Glioma | 55 | 12/55 | NA | HVRII, D-loop | Kirches et al. 2001 |
| Astrocytoma | 12 | 11/12b | NA | HVRII | Kirches et al. 1999 |
a Number of tumors with mutations/number of tumors
b 2 of the 12 astrocytomas were compared to adjacent brain, the remaining 10 were aligned to Anderson et al. 1981 for mutation analysis
c Number of mutations causing amino acid substitutions/total number of mutations found in all tumors
d NA, not applicable because in hypervariable region of the D-loop (HVR)