Table 4.
Transmission of Alleles at Selected SNPs in the Parent-Proband Trios[Note]
|
No. (%) of Alleles |
||||
| Gene, SNP, and Transmission | 1 | 2 | P | OR (95% CI)a |
| MRS2L: | ||||
| rs2793422: | ||||
| Transmitted | 191 (71) | 79 (29) | ||
| Nontransmitted | 168 (62) | 102 (38) | .04 | 1.47 (1.02–2.1) |
| KIAA0319: | ||||
| rs4504469: | ||||
| Transmitted | 166 (68) | 78 (32) | ||
| Nontransmitted | 144 (59) | 100 (41) | .04 | 1.48 (1.02–2.14) |
| rs2179515: | ||||
| Transmitted | 184 (71) | 77 (30) | ||
| Nontransmitted | 162 (62) | 99 (38) | .04 | 1.46 (1.01–2.10) |
| rs6935076: | ||||
| Transmitted | 154 (56) | 120 (44) | ||
| Nontransmitted | 189 (69) | 85 (31) | .002 | .57 (.41–.82) |
| rs2038137: | ||||
| Transmitted | 169 (69) | 77 (31) | ||
| Nontransmitted | 152 (62) | 94 (38) | .11 | 1.36 (.94–1.97) |
| THEM2: | ||||
| rs3777664: | ||||
| Transmitted | 165 (74) | 59 (26) | ||
| Nontransmitted | 144 (64) | 80 (36) | .03 | 1.55 (1.04–2.33) |
| Intergenic: | ||||
| rs1053598: | ||||
| Transmitted | 186 (76) | 59 (24) | ||
| Nontransmitted | 160 (65) | 85 (35) | .01 | 1.67 (1.13–2.48) |
Note.— P values for association were calculated using UNPHASED (Rosalind Franklin Centre for Genomics Research). P values ⩽.05 are indicated in bold italics.
a
ORs and 95% CIs refer to allele 1.