Figure 4.
Changes in LS bone size and mass during childhood, according to LRP5 exon 9 c.2047 genotypes and haplotypes. Mean changes (±SEM) in LS BMC and projected area were evaluated between baseline and 1 year in prepubertal males (M) and females (F). Panel A shows mean changes according to c.2047 genotypes, panel B according to reduced haplotype combinations, as in figure 3B. The number of females/males in each group is as follows: 0′,0′, n=109/168; 0′,3, n=22/38; 0′,4, n=16/29. Significant P values for differences between exon 9 genotypes and between haplotypes 3 and 4 are shown.