TABLE 1.
HIV-1 viral load and bulk sequencing at baseline, week 4, and week 12 (W12)a
| Patient | HIV-1 subtype | Baseline
|
Wk 4
|
Wk 12
|
|||
|---|---|---|---|---|---|---|---|
| pVLb | Bulk sequencingc | pVL | Bulk sequencing | pVL | Bulk sequencing | ||
| 1 | A | 507,000 | WT (S68G) | 273 | WT (S68G) | 100 | WT (S68G) |
| 2 | A | 37,000 | WT | 430 | WT | 1,100 | M184M/V |
| 3 | B | 367,000 | WT | 2,250 | WT | 7,070 | K65R,M184V |
| 4 | CRF02_AG | 21,000 | WT | 4,480 | WT | 412 | WT |
| 5 | B | 70,200 | WT | 1,100 | WT | 62 | M184V |
| 6 | CRF02_AG | 554,000 | WT | 684 | WT | 2,540 | K65K/R,M184M/V |
| 7 | CRF02_AG | 26,900 | WT | 80 | NAe | 344 | K65K/R,M184V |
| 8 | B | 106,000 | WT (S68G) | 4,040 | M184V (S68G) | 9,280 | K65R,M184V (S68G) |
| 9 | CRF02_AG | 757,000 | WT | NDd | M184V (S68G) | 3,170 | K65K/R,M184V (S68G) |
| 10 | B | 685,000 (68,500) | WT | 366,000 (36600) | M184V | 92,400 (9,240) | K65K/R,M184V |
| 11 | F2 | 134,000 | WT | 2,300 | M184M/V | 14,100 | K65K/R,M184V |
| 12 | B | 75,900 (7,590) | WT | 12,800 (1,280) | M184M/V | 21,100 (2,110) | K65R,M184V,1181 |
| 13 | B | 72,400 | WT | 1,560 | M184M/V | 4,790 | K65R,M184V |
| 14 | ND | 114,000 | WT | ND | M184M/V | 50 | ND |
| 15 | CRF02_AG | 72,200 | WT | 485 | M184M/I/V | 1,760 | M184V |
| 16 | B | 75,000 (7,500) | WT | 2,070 (270) | M184M/I | 6,530 (653) | K65R,M184V |
| 17 | B | 106,000 | WT | 49,600 | M184I/V | 25,700 | K65R,M184V |
| 18 | D | 344,000 | WT | 260 | M184I | 230 | M184I |
| 19 | B | 103,000 (10,300) | T215E (S68G) | 337 (70) | K65K/R,T215E (S68G) | 885 (177) | K65R,M184V,T215E(S68G) |
| 20 | B | 75,000 (7,500) | WT | 956 (191) | K65K/R;M184M/I | 4,540 (454) | K65K/R,M184V |
| 21 | B | 131,000 | WT | 220 | ND | 410 | M184M/I/V |
Cloning experiments were performed for patients 10, 12, 16, 19, 20 (highlighted in boldface).
pVL, HIV-1 plasma viral load. Numbers in parentheses indicate number of HIV-1 RNA copies per RT-PCR used in cloning experiments.
Parentheses indicate mutations not described in the IAS-USA mutations panel; shills indicate a mixed population. WT, wild type.
ND, not done.
NA, not available.