Table 6.
Analysis of preferences for alternative splicing and polyadenylation site variation among spliced COPs genes, in dependence of the termination site of the antisense transcript
| Spliced COP genes with an antisense transcript not overlapping a sense transcript intron region, show a significant negative bias for alternative splicing | |||
| COPs genes | COPs with antisense gene ending 3,000-0 bp before the sense I/E boundary | p-value | |
| Spliced genes | 1,723 | 1,497 | |
| Alternatively spliced genes | 268 (15.6%) | 217 (14.5%) | 0.0018 |
| Spliced COPs genes with an antisense transcript overlapping a sense transcript intron region, show a significant positive bias for alternative splicing | |||
| COPs genes | COPs with an antisense gene ending 0-3,000 bp behind the sense I/E boundary | p-value | |
| Gene with splicing | 1,723 | 226 | |
| Alternative splicing | 268 (15.6%) | 51 (22.6%) | 0.0018 |
| COPs genes | COPs with an antisense gene ending > 40 bp behind the sense I/E boundary | p-value | |
| Gene with splicing | 1,723 | 129 | |
| Alternative splicing | 268 (15.6%) | 35 (27.1%) | 0.00032 |
| Alternatively spliced COPs sense genes with an antisense transcript ending more than 40 bp behind their last I/E boundary, show a positive bias for polyadenylation site variation | |||
| COPs genes | COPs with an antisense gene ending > 40 bp behind the sense I/E boundary | p-value | |
| Alternatively spliced | 268 | 35 | |
| Polyadenylation site variation | 107 (39.9%) | 25 (71.4%) | 5.5e-05 |