Figure 1.
Craniofacial and cardiac defects in mutant mice (P0-Cre/Apc580S/580S). (A and B) Lateral (A) and frontal (B) views of a wild-type littermate (Left) and a mutant (Right) at birth. (C) Lateral views of faces of a wild-type littermate (Left) and a mutant (Right). (D) Lateral views of skeletal preparations of a P0-Cre/Apc580S/+ mouse (Left) and a mutant (Right) at 18.5 dpc. Part of the frontal bone is abnormal in mutants (arrow). fr, frontal; pr, parietal; eo, exoccipital; md, mandibullar bone. (E) Ventral views of skeletal preparations of a P0-Cre/Apc580S/+ mouse (Left) and a mutant (Right) at 18.5 dpc. n, nasal; mx, maxillary; j, jugal; ps, presphenoid; bs, basisphenoid; as, alisphenoid; tr, tympanic ring; bo, basioccipital bone. (F) Coronal sections of the trunk of P0-Cre/Apc580S/+ mice and mutants at 15.5 dpc. A ventricular septal defect (VSD) is shown in the heart of a mutant (arrow in Upper Right). The aorta and pulmonary artery are still adjoined and the pulmonary artery comes directly from the truncus arteriosus (arrow in Lower Right) in another mutant. RV, right ventricle; LV, left ventricle; Ao, aorta; PA, pulmonary artery. [Scale bars, 1 mm (A–E) and 0.5 mm (F).]