FIG. 5.
Granuloma necrosis in M. avium-infected p55−/− mice. Mice were intravenously infected with 106 CFU of M. avium TMC724 and sacrificed 5 to 6 weeks postinfection for histological analysis of the liver. (A) Necrotizing granuloma (HE; magnification, ×200); (B) early necrotizing granuloma (X) and completely disintegrated granuloma (arrow) with leakage into adjacent liver tissue (✶) (HE; magnification, ×128); (C) low-power view of multiple foci of granuloma necrosis with incipient damage (arrows) to surrounding liver tissue (HE; magnification, ×64).