FIG. 2.
Analysis of the transduction pattern 1 week after intraventricular injection of P0.5 mice. AAV2-HβH transduction was observed in the pial surface, brain parenchyma, and meninges of vector-injected (A, C, E, G, I, K, M, O, and Q) but not saline-injected (B, D, F, H, J, L, N, P, and R) control brains. Robust expression was also detected in the MCL of the main olfactory bulb (O) and in the ventralmost region of the granule cell layer of the dentate gyrus (Q). This ventralmost region is in direct contact with the CSF via the interpeduncular cistern and may provide an accessible pathway for AAV2 penetration into the dentate gyrus. Scale bars: 200 μm (A and B), 500 μm(C, D, G, H, I, J, M, N, O, and P), 60 μm (E, F, Q, and R), and 100 μm (K and L). Abbreviations: IC, inferior colliculus; SC, superior colliculus; TT, tenia tecta. See Fig. 1 legend for other abbreviations.