FIG. 4.
Structure of TBE virus envelope protein. (A) Top view of the E protein homodimer. (B) Side view of the E protein homodimer. Orientation nomenclature is adapted from that of Rey et al. (13), where top suggests a view towards and normal to the virus surface, and side suggests a view tangent to the virus surface, with the viral membrane below the protein. Each monomer of the homodimer is shaded differently, and the dashed lines delineate the domain III boundaries. (C) Isolated domain III viewed approximately perpendicular to the twofold axis of the E protein homodimer, corresponding to the solvent-exposed lateral surface of domain III. Positions of conserved vector-specific residues and insertions in domain III are indicated with spheres. Amino acid numbering refers to the TBE virus residue positions. Domain III structures were displayed using Swiss-Pdb Viewer (5; http://www.expasy.ch/spdbv).