Table 2.
A summary of the circRNA/miRNA axis in the regulation of tumorigenesis in human cancer.
| Cancer type | Molecular pathway | Remarks | Reference |
|---|---|---|---|
| Colorectal cancer | Circ-0026416/miR-346/NFIB | Circ-0026,416 sponges miR-346 to increase NFIB expression and promote tumorigenesis | [51] |
| Cervical cancer | Circ-0084927/miR-142–3p/ARL2 | Circ-0084,927 enhances tumorigenesis by decreasing miR-142–3p expression and upregulating ARL2 | [52] |
| Colorectal cancer | Circ0005927/miR-942–5p/BATF2 | Downregulation of miR-942–5p by circ-0005927 to increase BATF2 expression and impair tumorigenesis | [53] |
| Prostate cancer | Hsa_circ_0007494/miR-616/PTEN | Circ-0007494 sponges miR-616 in increasing PTEN expression and suppressing tumorigenesis | [54] |
| Gastric cancer | Circ0027599/miR-21–5p/RUNX1 | Circ0027,599 reduces miR-21–5p expression to enhance RUNX1 expression and promote carcinogenesis | [55] |
| Colorectal cancer | Circ-ACAP2/miR-143–3p/FZD4 | Circ-ACAP2 sponges miR-143–3p to increase FZD4 expression in cancer suppression | [56] |
| Colorectal cancer | Circ0067835/miR-296–5p/IGF1R | Upregulation of IGFR1 by circ-0067,835 through miR-296–5p sponging in reducing radiosensitivity | [57] |
| Colorectal cancer | Hsa_circ_001680/miR-340/BMI1 | Oncogenic function of circ-001680 in enhancing tumor progression | [58] |
| Lung cancer | Hsa_circ_100395/miR-1228/TCF21 | Circ-100395 upregulates TCF21 expression through miR-12228 sponging in reducing tumor progression | [59] |