TABLE 6.
TK mutations identified in ACV-selected HSV-1 SC16
| Clonal virus | Mutationa
|
Predicted length (aa)b | |
|---|---|---|---|
| Nucleotide | Amino acid | ||
| 1A1 | C860T; ΔG919 | T287M; FS 307 | 346 |
| 1A2 | ΔC553 | FS 185 | 346 |
| 1A3 | +G437 | FS 146 | 227 |
| 1A4 | G176C; +G437 | G59A; FS 146 | 227 |
| 1A5 | C148G; +G437 | L50V; FS 146 | 227 |
| 1A6 | C860T | T287M | 376 |
| 1A7 | C13G; T21A; +2G437; ΔC462 | P5A; H7Q; FS 146; FS 153 | 227 |
| 1A8 | C13G; +G437 | P5A; FS 146 | 227 |
| 1A9 | C860T; +C886; +T893; +GCC896; +A901; +G905; +G919 | T287M; FS 296, 298, 301, 302, 307 | 349 |
| 1A11-A | G16T; +G437 | G6C; FS 146 | 227 |
| 1A11-B | +G437 | FS 146 | 227 |
| 1A12 | G16T; +G437 | G6C; FS 146 | 227 |
| 1A13 | G16T; G167T; +G437 | G6C; G56V; FS 146 | 227 |
| 1A14 | C13G; T21A; +G437 | P5A; H7Q; FS 146 | 227 |
a
The designation C148G represents a change from the wild-type nucleotide C to a G at base 148; the others follow this pattern. Δ, base deletion; +, base insertion; FS, frameshift in the coding sequence.
b
aa, amino acids.