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. 1987 Jan;40(1):34–41. doi: 10.1136/jcp.40.1.34

Major histocompatibility complex class II antigen expression in B and T cell non-Hodgkin's lymphoma.

M E Smith, C S Holgate, J M Williamson, I Grigor, P Quirke, C C Bird
PMCID: PMC1140825  PMID: 3546388

Abstract

An immunohistochemical study of 46 B and T cell non-Hodgkin's lymphomas, using monoclonal antibodies to the products of the major histocompatibility complex (MHC) class II antigen subregions, DP, DQ, and DR, showed that most B and T cell lymphomas express these antigens. Both coordinate and non-coordinate expression of MHC class II antigens was observed, but this did not correlate with immunological phenotype, morphological grade, or proliferation index as determined by flow cytometry.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brodsky F. M. A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. Immunogenetics. 1984;19(3):179–194. doi: 10.1007/BF00364762. [DOI] [PubMed] [Google Scholar]
  2. Effros R. B., Dillard L., Zeller E., Naeim F., Walford R. L. Strong HLA-DR expression in T cell cultures after activation is necessary for IL-2-dependent proliferation. Hum Immunol. 1983 Dec;8(4):249–254. doi: 10.1016/0198-8859(83)90051-4. [DOI] [PubMed] [Google Scholar]
  3. Epenetos A. A., Bobrow L. G., Adams T. E., Collins C. M., Isaacson P. G., Bodmer W. F. A monoclonal antibody that detects HLA-D region antigen in routinely fixed, wax embedded sections of normal and neoplastic lymphoid tissues. J Clin Pathol. 1985 Jan;38(1):12–17. doi: 10.1136/jcp.38.1.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Guy K., Krajewski A. S., Dewar A. E. Expression of MHC class II antigens in human B-cell leukaemia and non-Hodgkin's lymphoma. Br J Cancer. 1986 Feb;53(2):161–173. doi: 10.1038/bjc.1986.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Guy K., Van Heyningen V., Cohen B. B., Deane D. L., Steel C. M. Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains. Eur J Immunol. 1982 Nov;12(11):942–948. doi: 10.1002/eji.1830121109. [DOI] [PubMed] [Google Scholar]
  6. Hedley D. W., Friedlander M. L., Taylor I. W., Rugg C. A., Musgrove E. A. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem. 1983 Nov;31(11):1333–1335. doi: 10.1177/31.11.6619538. [DOI] [PubMed] [Google Scholar]
  7. Kehrl J. H., Muraguchi A., Fauci A. S. The modulation of membrane Ia on human B lymphocytes. Cell Immunol. 1985 May;92(2):391–403. doi: 10.1016/0008-8749(85)90020-6. [DOI] [PubMed] [Google Scholar]
  8. Krajewski A. S., Guy K., Dewar A. E., Cossar D. Immunohistochemical analysis of human MHC class II antigens in B-cell non-Hodgkin's lymphomas. J Pathol. 1985 Feb;145(2):185–194. doi: 10.1002/path.1711450206. [DOI] [PubMed] [Google Scholar]
  9. Lampson L. A., Levy R. Two populations of Ia-like molecules on a human B cell line. J Immunol. 1980 Jul;125(1):293–299. [PubMed] [Google Scholar]
  10. Lauder I., Bird C. C., Child J. A., Grigor I. Surface membrane phenotypic expression and treatment response of malignant lymphomas. J Pathol. 1985 Mar;145(3):259–268. doi: 10.1002/path.1711450307. [DOI] [PubMed] [Google Scholar]
  11. Moretta A., Accolla R. S., Cerottini J. C. IL-2-mediated T cell proliferation in humans is blocked by a monoclonal antibody directed against monomorphic determinants of HLA-DR antigens. J Exp Med. 1982 Feb 1;155(2):599–604. doi: 10.1084/jem.155.2.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nuñez G., Giles R. C., Ball E. J., Hurley C. K., Capra J. D., Stastny P. Expression of HLA-DR, MB, MT and SB antigens on human mononuclear cells: identification of two phenotypically distinct monocyte populations. J Immunol. 1984 Sep;133(3):1300–1306. [PubMed] [Google Scholar]
  13. Pober J. S., Collins T., Gimbrone M. A., Jr, Cotran R. S., Gitlin J. D., Fiers W., Clayberger C., Krensky A. M., Burakoff S. J., Reiss C. S. Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature. 1983 Oct 20;305(5936):726–729. doi: 10.1038/305726a0. [DOI] [PubMed] [Google Scholar]
  14. Quirke P., Fozard J. B., Dixon M. F., Dyson J. E., Giles G. R., Bird C. C. DNA aneuploidy in colorectal adenomas. Br J Cancer. 1986 Apr;53(4):477–481. doi: 10.1038/bjc.1986.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Reinherz E. L., Kung P. C., Pesando J. M., Ritz J., Goldstein G., Schlossman S. F. Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med. 1979 Dec 1;150(6):1472–1482. doi: 10.1084/jem.150.6.1472. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Shaw A. R., Chan J. K., Reid S., Seehafer J. HLA-DR synthesis induction and expression in HLA-DR-negative carcinoma cell lines of diverse origins by interferon-gamma but not by interferon-beta. J Natl Cancer Inst. 1985 Jun;74(6):1261–1268. [PubMed] [Google Scholar]
  17. Sunderland C. A., Naiem M., Mason D. Y., Redman C. W., Stirrat G. M. The expression of major histocompatibility antigens by human chorionic villi. J Reprod Immunol. 1981 Dec;3(6):323–331. doi: 10.1016/0165-0378(81)90048-6. [DOI] [PubMed] [Google Scholar]
  18. Swerdlow S. H., Murray L. J., Habeshaw J. A., Stansfeld A. G. Lymphocytic lymphoma/B-chronic lymphocytic leukaemia--an immunohistopathological study of peripheral B lymphocyte neoplasia. Br J Cancer. 1984 Nov;50(5):587–599. doi: 10.1038/bjc.1984.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Watson A. J., DeMars R., Trowbridge I. S., Bach F. H. Detection of a novel human class II HLA antigen. 1983 Jul 28-Aug 3Nature. 304(5924):358–361. doi: 10.1038/304358a0. [DOI] [PubMed] [Google Scholar]
  20. Weiss L. M., Crabtree G. S., Rouse R. V., Warnke R. A. Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Am J Pathol. 1985 Feb;118(2):316–324. [PMC free article] [PubMed] [Google Scholar]
  21. Weiss L. M., Wood G. S., Warnke R. A. Immunophenotypic differences between dermatopathic lymphadenopathy and lymph node involvement in mycosis fungoides. Am J Pathol. 1985 Aug;120(2):179–185. [PMC free article] [PubMed] [Google Scholar]
  22. van Heyningen V., Guy K., Newman R., Steel C. M. Human MHC class II molecules as differentiation markers. Immunogenetics. 1982;16(5):459–469. doi: 10.1007/BF00372104. [DOI] [PubMed] [Google Scholar]

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