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Decreased inflammation in lungs of M. tuberculosis–infected 5-LO–deficient mice. Representative H&E-stained sections of lungs from 50-day–infected (300 CFU inoculum) B6, 129S F2/J control (A and B) and 5-LO–deficient (C and D) animals. Note the reduction in inflammatory infiltration and greatly increased alveolar space in 5-lo–/– animals (C and D). Original magnification, ×5 (A and C) and ×40 (B and D).
