Table 3. Dynamic levels of retinoids in serum and liver of mice at 2 h after injection of retinol (50 mg/kg).
The results are expressed as the means±S.E.M. (n=3). All mice examined were females at 10 weeks of age. Note that values are in μg/g (or ml). *P<0.05 compared with wild-type mice. †P<0.05 compared with Crbp1−/− mice.
| Serum | Liver | ||||
|---|---|---|---|---|---|
| Genotype | All-trans-RA (μg/ml) | All-trans-retinol (μg/ml) | All-trans-RA (μg/g) | All-trans-retinol (μg/g) | Retinyl esters (μg/g) |
| Wild-type | 0.67±0.11 | 0.92±0.06 | 1.20±0.18 | 11.2±0.21 | 612±57 |
| Crbp1−/− | 2.26±0.34* | 1.80±0.04* | 3.58±0.53* | 12.1±0.65 | 209±9* |
| Crbp1−/−/Adh1−/− | 0.11±0.02† | 1.85±0.07* | 0.15±0.04† | 15.2±1.49* | 462±45† |
| Adh1−/− | 0.12±0.02* | 1.65±0.11* | 0.27±0.06* | 18.2±2.17* | 925±33 |