| TLRs |
Recognition of invariant microbial molecules (e.g. TLR4/LPS). |
[2] |
|
Induction of innate immune response. |
|
| TNF receptor family (e.g. TNFR1, CD40, LTβR) |
Regulation of development and function of immune system |
[189] |
| TRAF proteins |
Intracellular adapter proteins |
[71] |
| MAP kinase pathway [MAP 3-K (e.g. TPL-2); MAP 2-kinase (e.g. MEK); MAP-kinase (e.g. ERK)] |
Intracellular signalling cascade |
[190] |
| IKK complex (IKK1/IKK2/NEMO) |
Multisubunit protein complex; regulation of IκB proteolysis |
[24] |
| IκB proteins (IκBα, IκBβ, IκBε, NF-κB1 p105, NF-κB2 p100) |
NF-κB inhibitors |
[15] |
| NF-κB (Rel) proteins (RelA, RelB, c-Rel, NF-κB1 p50, NF-κB2 p52) |
Dimeric transcription factors |
[15] |
| Ubiquitination |
Covalent protein modification; regulates target protein stability or function |
[27] |
| E3 ligase (e.g. SCFβTrCP) |
Substrate recognition and ubiquitin transfer |
[27] |
| Proteasome |
Multisubunit protease; proteolysis of ubiquitinated proteins (e.g. IκBs) |
[28] |
