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. 1989 Oct 15;263(2):313–323. doi: 10.1042/bj2630313

Fuel selection and carbon flux during the starved-to-fed transition.

M C Sugden 1, M J Holness 1, T N Palmer 1
PMCID: PMC1133432  PMID: 2688629

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adkins B. A., Myers S. R., Hendrick G. K., Stevenson R. W., Williams P. E., Cherrington A. D. Importance of the route of intravenous glucose delivery to hepatic glucose balance in the conscious dog. J Clin Invest. 1987 Feb;79(2):557–565. doi: 10.1172/JCI112847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Agius L., Williamson D. H. Lipogenesis in interscapular brown adipose tissue of virgin, pregnant and lactating rats. The effects of intragastric feeding. Biochem J. 1980 Aug 15;190(2):477–480. doi: 10.1042/bj1900477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Agius L., Williamson D. H. The utilization of ketone bodies by the interscapular brown adipose tissue of the rat. Biochim Biophys Acta. 1981 Oct 23;666(1):127–132. doi: 10.1016/0005-2760(81)90098-9. [DOI] [PubMed] [Google Scholar]
  4. Barrett E. J., Gusberg R., Ferrannini E., Tepler J., Felig P., Jacob R., Smith D., DeFronzo R. A. Amino acid and glucose metabolism in the postabsorptive state and following amino acid ingestion in the dog. Metabolism. 1986 Aug;35(8):709–717. doi: 10.1016/0026-0495(86)90238-6. [DOI] [PubMed] [Google Scholar]
  5. Baxter M. A., Coore H. G. The mode of regulation of pyruvate dehydrogenase of lactating rat mammary gland. Effects of starvation and insulin. Biochem J. 1978 Aug 15;174(2):553–561. doi: 10.1042/bj1740553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beale E. G., Katzen C. S., Granner D. K. Regulation of rat liver phosphoenolpyruvate carboxykinase (GTP) messenger ribonucleic acid activity by N6, O2'-dibutyryladenosine 3',5'-phosphate. Biochemistry. 1981 Aug 18;20(17):4878–4883. doi: 10.1021/bi00520a012. [DOI] [PubMed] [Google Scholar]
  7. Beggs M., Shaw J. M., Randle P. J. Longer-term regulation of branched-chain-2-oxoacid dehydrogenase complex studied in rat hepatocytes in culture. Biochem J. 1989 Jan 1;257(1):271–275. doi: 10.1042/bj2570271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Berger M., Hagg S. A., Goodman M. N., Ruderman N. B. Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem J. 1976 Aug 15;158(2):191–202. doi: 10.1042/bj1580191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bollen M., Gevers G., Stalmans W. The activity of glycogen synthase phosphatase limits hepatic glycogen deposition in the adrenalectomized starved rat. Biochem J. 1983 Aug 15;214(2):539–545. doi: 10.1042/bj2140539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bollen M., Stalmans W. Fluorine compounds inhibit the conversion of active type-1 protein phosphatases into the ATPMg-dependent form. Biochem J. 1988 Oct 1;255(1):327–333. [PMC free article] [PubMed] [Google Scholar]
  11. Bosca L., Challiss R. A., Newsholme E. A. The effect of fructose 2,6-bisphosphate on muscle fructose-1,6-bisphosphatase activity. Biochim Biophys Acta. 1985 Apr 5;828(2):151–154. doi: 10.1016/0167-4838(85)90051-2. [DOI] [PubMed] [Google Scholar]
  12. Brooks B. J., Arch J. R., Newsholme E. A. Effect of some hormones on the rate of the triacylglycerol/fatty-acid substrate cycle in adipose tissue of the mouse in vivo. Biosci Rep. 1983 Mar;3(3):263–267. doi: 10.1007/BF01122458. [DOI] [PubMed] [Google Scholar]
  13. Burnol A. F., Ferre P., Leturque A., Girard J. Effect of insulin on in vivo glucose utilization in individual tissues of anesthetized lactating rats. Am J Physiol. 1987 Feb;252(2 Pt 1):E183–E188. doi: 10.1152/ajpendo.1987.252.2.E183. [DOI] [PubMed] [Google Scholar]
  14. Caterson I. D., Fuller S. J., Randle P. J. Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats. Biochem J. 1982 Oct 15;208(1):53–60. doi: 10.1042/bj2080053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Cersosimo E., Williams P., Hoxworth B., Lacy W., Abumrad N. Glutamine blocks lipolysis and ketogenesis of fasting. Am J Physiol. 1986 Mar;250(3 Pt 1):E248–E252. doi: 10.1152/ajpendo.1986.250.3.E248. [DOI] [PubMed] [Google Scholar]
  16. Challiss R. A., Crabtree B., Newsholme E. A. Hormonal regulation of the rate of the glycogen/glucose-1-phosphate cycle in skeletal muscle. Eur J Biochem. 1987 Feb 16;163(1):205–210. doi: 10.1111/j.1432-1033.1987.tb10756.x. [DOI] [PubMed] [Google Scholar]
  17. Ciudad C. J., Massagué J., Guinovart J. J. The inactivation of glycogen phosphorylase is not a prerequisite for the activation of liver glycogen synthase. FEBS Lett. 1979 Mar 15;99(2):321–324. doi: 10.1016/0014-5793(79)80982-5. [DOI] [PubMed] [Google Scholar]
  18. Claus T. H., Nyfeler F., Muenkel H. A., Burns M. G., Pate T., Pilkis S. J. Changes in key regulatory enzymes of hepatic carbohydrate metabolism after glucose loading of starved rats. Biochem Biophys Res Commun. 1984 Dec 14;125(2):655–661. doi: 10.1016/0006-291x(84)90589-8. [DOI] [PubMed] [Google Scholar]
  19. Cohen P. The coordinated control of metabolic pathways by broad-specificity protein kinases and phosphatases. Curr Top Cell Regul. 1985;27:23–37. doi: 10.1016/b978-0-12-152827-0.50010-4. [DOI] [PubMed] [Google Scholar]
  20. Conlee R. K., Hickson R. C., Winder W. W., Hagberg J. M., Holloszy J. O. Regulation of glycogen resynthesis in muscles of rats following exercise. Am J Physiol. 1978 Sep;235(3):R145–R150. doi: 10.1152/ajpregu.1978.235.3.R145. [DOI] [PubMed] [Google Scholar]
  21. Cook E. B., Preece J. A., Tobin S. D., Sugden M. C., Cox D. J., Palmer T. N. Acute inhibition by ethanol of intestinal absorption of glucose and hepatic glycogen synthesis on glucose refeeding after starvation in the rat. Biochem J. 1988 Aug 15;254(1):59–65. doi: 10.1042/bj2540059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Cox D. J., Palmer T. N. Carcass glycogen repletion on carbohydrate re-feeding after starvation. Biochem J. 1987 Aug 1;245(3):903–905. doi: 10.1042/bj2450903. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Crettaz M., Prentki M., Zaninetti D., Jeanrenaud B. Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites. Biochem J. 1980 Feb 15;186(2):525–534. doi: 10.1042/bj1860525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Crettaz M., Zaninetti D., Jeanrenaud B. Insulin-resistance in heart and skeletal muscles of genetically obese Zucker rats. Biochem Soc Trans. 1981 Dec;9(6):524–525. doi: 10.1042/bst0090524. [DOI] [PubMed] [Google Scholar]
  25. De Wulf H., Stalmans W., Hers H. G. The effect of glucose and of a treatment by glucocorticoids on the activation in vitro of liver glycogen synthetase. Eur J Biochem. 1970 Jul;15(1):1–8. doi: 10.1111/j.1432-1033.1970.tb00967.x. [DOI] [PubMed] [Google Scholar]
  26. DeFronzo R. A., Ferrannini E., Koivisto V. New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus. Am J Med. 1983 Jan 17;74(1A):52–81. doi: 10.1016/0002-9343(83)90654-x. [DOI] [PubMed] [Google Scholar]
  27. DeFronzo R. A., Ferrannini E., Sato Y., Felig P., Wahren J. Synergistic interaction between exercise and insulin on peripheral glucose uptake. J Clin Invest. 1981 Dec;68(6):1468–1474. doi: 10.1172/JCI110399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. DeFronzo R. A. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 1988 Jun;37(6):667–687. doi: 10.2337/diab.37.6.667. [DOI] [PubMed] [Google Scholar]
  29. DeFronzo R. A., Simonson D., Ferrannini E. Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1982 Oct;23(4):313–319. doi: 10.1007/BF00253736. [DOI] [PubMed] [Google Scholar]
  30. DeFronzo R. A., Smith D., Alvestrand A. Insulin action in uremia. Kidney Int Suppl. 1983 Dec;16:S102–S114. [PubMed] [Google Scholar]
  31. DePaoli-Roach A. A., Ahmad Z., Camici M., Lawrence J. C., Jr, Roach P. J. Multiple phosphorylation of rabbit skeletal muscle glycogen synthase. Evidence for interactions among phosphorylation sites and the resolution of electrophoretically distinct forms of the subunit. J Biol Chem. 1983 Sep 10;258(17):10702–10709. [PubMed] [Google Scholar]
  32. Denton R. M., Randle P. J., Bridges B. J., Cooper R. H., Kerbey A. L., Pask H. T., Severson D. L., Stansbie D., Whitehouse S. Regulation of mammalian pyruvate dehydrogenase. Mol Cell Biochem. 1975 Oct 31;9(1):27–53. doi: 10.1007/BF01731731. [DOI] [PubMed] [Google Scholar]
  33. Denton R. M., Randle P. J. Concentrations of glycerides and phospholipids in rat heart and gastrocnemius muscles. Effects of alloxan-diabetes and perfusion. Biochem J. 1967 Aug;104(2):416–422. doi: 10.1042/bj1040416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Denyer G. S., Kerbey A. L., Randle P. J. Kinase activator protein mediates longer-term effects of starvation on activity of pyruvate dehydrogenase kinase in rat liver mitochondria. Biochem J. 1986 Oct 15;239(2):347–354. doi: 10.1042/bj2390347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Elia M., Folmer P., Schlatmann A., Goren A., Austin S. Carbohydrate, fat, and protein metabolism in muscle and in the whole body after mixed meal ingestion. Metabolism. 1988 Jun;37(6):542–551. doi: 10.1016/0026-0495(88)90169-2. [DOI] [PubMed] [Google Scholar]
  36. Fatania H. R., Vary T. C., Randle P. J. Modulation of pyruvate dehydrogenase kinase activity in cultured hepatocytes by glucagon and n-octanoate. Biochem J. 1986 Feb 15;234(1):233–236. doi: 10.1042/bj2340233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Felíu J. E., Hue L., Hers H. G. Regulation in vitro and in vivo of adenosine 3':5'-monophosphate-dependent inactivation of rat-liver pyruvate kinase type L. Eur J Biochem. 1977 Dec;81(3):609–617. doi: 10.1111/j.1432-1033.1977.tb11988.x. [DOI] [PubMed] [Google Scholar]
  38. Ferrannini E., Barrett E. J., Bevilacqua S., DeFronzo R. A. Effect of fatty acids on glucose production and utilization in man. J Clin Invest. 1983 Nov;72(5):1737–1747. doi: 10.1172/JCI111133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Ferrannini E., Bjorkman O., Reichard G. A., Jr, Pilo A., Olsson M., Wahren J., DeFronzo R. A. The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes. 1985 Jun;34(6):580–588. doi: 10.2337/diab.34.6.580. [DOI] [PubMed] [Google Scholar]
  40. Ferrannini E., Buzzigoli G., Bonadonna R., Giorico M. A., Oleggini M., Graziadei L., Pedrinelli R., Brandi L., Bevilacqua S. Insulin resistance in essential hypertension. N Engl J Med. 1987 Aug 6;317(6):350–357. doi: 10.1056/NEJM198708063170605. [DOI] [PubMed] [Google Scholar]
  41. Ferrannini E., Simonson D. C., Katz L. D., Reichard G., Jr, Bevilacqua S., Barrett E. J., Olsson M., DeFronzo R. A. The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism. 1988 Jan;37(1):79–85. doi: 10.1016/0026-0495(88)90033-9. [DOI] [PubMed] [Google Scholar]
  42. Ferré P., Burnol A. F., Leturque A., Terretaz J., Penicaud L., Jeanrenaud B., Girard J. Glucose utilization in vivo and insulin-sensitivity of rat brown adipose tissue in various physiological and pathological conditions. Biochem J. 1986 Jan 1;233(1):249–252. doi: 10.1042/bj2330249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Ferré P., Leturque A., Burnol A. F., Penicaud L., Girard J. A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat. Biochem J. 1985 May 15;228(1):103–110. doi: 10.1042/bj2280103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Fiol C. J., Mahrenholz A. M., Wang Y., Roeske R. W., Roach P. J. Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem. 1987 Oct 15;262(29):14042–14048. [PubMed] [Google Scholar]
  45. Foulkes J. G., Cohen P., Strada S. J., Everson W. V., Jefferson L. S. Antagonistic effects of insulin and beta-adrenergic agonists on the activity of protein phosphatase inhibitor-1 in skeletal muscle of the perfused rat hemicorpus. J Biol Chem. 1982 Nov 10;257(21):12493–12496. [PubMed] [Google Scholar]
  46. French T. J., Goode A. W., Holness M. J., MacLennan P. A., Sugden M. C. The relationship between changes in lipid fuel availability and tissue fructose 2,6-bisphosphate concentrations and pyruvate dehydrogenase complex activities in the fed state. Biochem J. 1988 Dec 15;256(3):935–939. doi: 10.1042/bj2560935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. French T. J., Holness M. J., Goode A. W., Sugden M. C. Acute effects of surgery on carbohydrate production and utilization in the fed rat. Clin Sci (Lond) 1988 Jan;74(1):107–112. doi: 10.1042/cs0740107. [DOI] [PubMed] [Google Scholar]
  48. French T. J., Holness M. J., MacLennan P. A., Sugden M. C. Effects of nutritional status and acute variation in substrate supply on cardiac and skeletal-muscle fructose 2,6-bisphosphate concentrations. Biochem J. 1988 Mar 15;250(3):773–779. doi: 10.1042/bj2500773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Gardemann A., Strulik H., Jungermann K. A portal-arterial glucose concentration gradient as a signal for an insulin-dependent net glucose uptake in perfused rat liver. FEBS Lett. 1986 Jul 7;202(2):255–259. doi: 10.1016/0014-5793(86)80697-4. [DOI] [PubMed] [Google Scholar]
  50. Garetto L. P., Richter E. A., Goodman M. N., Ruderman N. B. Enhanced muscle glucose metabolism after exercise in the rat: the two phases. Am J Physiol. 1984 Jun;246(6 Pt 1):E471–E475. doi: 10.1152/ajpendo.1984.246.6.E471. [DOI] [PubMed] [Google Scholar]
  51. Gergely P., Tóth B., Farkas I., Bot G. Effect of fructose 1-phosphate on the activation of liver glycogen synthase. Biochem J. 1985 Nov 15;232(1):133–137. doi: 10.1042/bj2320133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Goodman M. N., del Pilar Gomez M. Decreased myofibrillar proteolysis after refeeding requires dietary protein or amino acids. Am J Physiol. 1987 Jul;253(1 Pt 1):E52–E58. doi: 10.1152/ajpendo.1987.253.1.E52. [DOI] [PubMed] [Google Scholar]
  53. Goodridge A. G., Back D. W., Wilson S. B., Goldman M. J. Regulation of genes for enzymes involved in fatty acid synthesis. Ann N Y Acad Sci. 1986;478:46–62. doi: 10.1111/j.1749-6632.1986.tb15520.x. [DOI] [PubMed] [Google Scholar]
  54. Granner D. K., Andreone T. L. Insulin modulation of gene expression. Diabetes Metab Rev. 1985;1(1-2):139–170. doi: 10.1002/dmr.5610010108. [DOI] [PubMed] [Google Scholar]
  55. Granner D. K., Sasaki K., Chu D. Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. Ann N Y Acad Sci. 1986;478:175–190. doi: 10.1111/j.1749-6632.1986.tb15530.x. [DOI] [PubMed] [Google Scholar]
  56. Grantham B. D., Zammit V. A. Restoration of the properties of carnitine palmitoyltransferase I in liver mitochondria during re-feeding of starved rats. Biochem J. 1986 Oct 15;239(2):485–488. doi: 10.1042/bj2390485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Halimi S., Assimacopoulos-Jeannet F., Terrettaz J., Jeanrenaud B. Differential effect of steady-state hyperinsulinaemia and hyperglycaemia on hepatic glycogenolysis and glycolysis in rats. Diabetologia. 1987 Apr;30(4):268–272. doi: 10.1007/BF00270426. [DOI] [PubMed] [Google Scholar]
  58. Harris A. R., Fang S. L., Vagenakis A. G., Braverman L. E. Effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the rat. Metabolism. 1978 Nov;27(11):1680–1690. doi: 10.1016/0026-0495(78)90290-1. [DOI] [PubMed] [Google Scholar]
  59. Hems D. A., Rath E. A., Verrinder T. R. Fatty acid synthesis in liver and adipose tissue of normal and genetically obese (ob/ob) mice during the 24-hour cycle. Biochem J. 1975 Aug;150(2):167–173. doi: 10.1042/bj1500167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Hod Y., Cook J. S., Weldon S. L., Short J. M., Wynshaw-Boris A., Hanson R. W. Differential expression of the genes for the mitochondrial and cytosolic forms of phosphoenolpyruvate carboxykinase. Ann N Y Acad Sci. 1986;478:31–45. doi: 10.1111/j.1749-6632.1986.tb15519.x. [DOI] [PubMed] [Google Scholar]
  61. Holness M. J., Cook E. B., Sugden M. C. Regulation of hepatic fructose 2,6-bisphosphate concentrations and lipogenesis after re-feeding in euthyroid and hyperthyroid rats. A regulatory role for glycogenesis. Biochem J. 1988 Jun 1;252(2):357–362. doi: 10.1042/bj2520357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  62. Holness M. J., French T. J., Schofield P. S., Sugden M. C. The relationship between fat synthesis and oxidation in the liver after re-feeding and its regulation by thyroid hormone. Biochem J. 1987 Nov 1;247(3):621–626. doi: 10.1042/bj2470621. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. Holness M. J., French T. J., Sugden M. C. Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. A regulatory role for pyruvate dehydrogenase in liver and extrahepatic tissues. Biochem J. 1986 Apr 15;235(2):441–445. doi: 10.1042/bj2350441. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Holness M. J., MacLennan P. A., Palmer T. N., Sugden M. C. The disposition of carbohydrate between glycogenesis, lipogenesis and oxidation in liver during the starved-to-fed transition. Biochem J. 1988 Jun 1;252(2):325–330. doi: 10.1042/bj2520325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Holness M. J., Palmer T. N., Sugden M. C. Effects of administration of tri-iodothyronine on the response of cardiac and renal pyruvate dehydrogenase complex to starvation for 48 h. Biochem J. 1985 Nov 15;232(1):255–259. doi: 10.1042/bj2320255. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Holness M. J., Palmer T. N., Worrall E. B., Sugden M. C. Hepatic carbon flux after re-feeding in the glycogen-storage-disease (gsd/gsd) rat. Biochem J. 1987 Dec 15;248(3):969–972. doi: 10.1042/bj2480969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Holness M. J., Schuster-Bruce M. J., Sugden M. C. Skeletal-muscle glycogen synthesis during the starved-to-fed transition in the rat. Biochem J. 1988 Sep 15;254(3):855–859. doi: 10.1042/bj2540855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Holness M. J., Sugden M. C. Continued glucose output after re-feeding contributes to glucose intolerance in hyperthyroidism. Biochem J. 1987 Nov 1;247(3):801–804. doi: 10.1042/bj2470801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Holness M. J., Sugden M. C. Hepatic carbon flux after re-feeding. Hyperthyroidism blocks glycogen synthesis and the suppression of glucose output observed in response to carbohydrate re-feeding. Biochem J. 1987 Nov 1;247(3):627–634. doi: 10.1042/bj2470627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Holness M. J., Sugden M. C. Pyruvate dehydrogenase activities during the fed-to-starved transition and on re-feeding after acute or prolonged starvation. Biochem J. 1989 Mar 1;258(2):529–533. doi: 10.1042/bj2580529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Holness M. J., Sugden M. C. Regulation of renal and hepatic pyruvate dehydrogenase complex on carbohydrate re-feeding after starvation. Possible mechanisms and a regulatory role for thyroid hormone. Biochem J. 1987 Jan 15;241(2):421–425. doi: 10.1042/bj2410421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Huang M. T., Veech R. L. Role of the direct and indirect pathways for glycogen synthesis in rat liver in the postprandial state. J Clin Invest. 1988 Mar;81(3):872–878. doi: 10.1172/JCI113397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Hue L., Blackmore P. F., Shikama H., Robinson-Steiner A., Exton J. H. Regulation of fructose-2,6-bisphosphate content in rat hepatocytes, perfused hearts, and perfused hindlimbs. J Biol Chem. 1982 Apr 25;257(8):4308–4313. [PubMed] [Google Scholar]
  74. Hue L., Rider M. H. Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem J. 1987 Jul 15;245(2):313–324. doi: 10.1042/bj2450313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Hutson N. J., Randle P. J. Enhanced activity of pyruvate dehydrogenase kinase in rat heart mitochondria in alloxan-diabetes or starvation. FEBS Lett. 1978 Aug 1;92(1):73–76. doi: 10.1016/0014-5793(78)80724-8. [DOI] [PubMed] [Google Scholar]
  76. Issad T., Pénicaud L., Ferré P., Kandé J., Baudon M. A., Girard J. Effects of fasting on tissue glucose utilization in conscious resting rats. Major glucose-sparing effect in working muscles. Biochem J. 1987 Aug 15;246(1):241–244. doi: 10.1042/bj2460241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Ivy J. L., Holloszy J. O. Persistent increase in glucose uptake by rat skeletal muscle following exercise. Am J Physiol. 1981 Nov;241(5):C200–C203. doi: 10.1152/ajpcell.1981.241.5.C200. [DOI] [PubMed] [Google Scholar]
  78. Iynedjian P. B., Ucla C., Mach B. Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver. J Biol Chem. 1987 May 5;262(13):6032–6038. [PubMed] [Google Scholar]
  79. Jackson R. A., Hamling J. B., Sim B. M., Hawa M. I., Blix P. M., Nabarro J. D. Peripheral lactate and oxygen metabolism in man: the influence of oral glucose loading. Metabolism. 1987 Feb;36(2):144–150. doi: 10.1016/0026-0495(87)90008-4. [DOI] [PubMed] [Google Scholar]
  80. James D. E., Jenkins A. B., Kraegen E. W. Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in rats. Am J Physiol. 1985 May;248(5 Pt 1):E567–E574. doi: 10.1152/ajpendo.1985.248.5.E567. [DOI] [PubMed] [Google Scholar]
  81. Jeanrenaud B. Hyperinsulinemia in obesity syndromes: its metabolic consequences and possible etiology. Metabolism. 1978 Dec;27(12 Suppl 2):1881–1892. doi: 10.1016/s0026-0495(78)80006-7. [DOI] [PubMed] [Google Scholar]
  82. Jeanrenaud B. Insulin and obesity. Diabetologia. 1979 Sep;17(3):133–138. doi: 10.1007/BF01219738. [DOI] [PubMed] [Google Scholar]
  83. Jenkins A. B., Storlien L. H., Chisholm D. J., Kraegen E. W. Effects of nonesterified fatty acid availability on tissue-specific glucose utilization in rats in vivo. J Clin Invest. 1988 Jul;82(1):293–299. doi: 10.1172/JCI113586. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Jones R. G., Ilic V., Williamson D. H. Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state. Biochem J. 1984 Oct 15;223(2):345–351. doi: 10.1042/bj2230345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Joost H. G., Steinfelder H. J. Insulin-like stimulation of glucose transport in isolated adipocytes by fatty acids. Biochem Biophys Res Commun. 1985 May 16;128(3):1358–1363. doi: 10.1016/0006-291x(85)91090-3. [DOI] [PubMed] [Google Scholar]
  86. Jungermann K. Metabolic zonation of liver parenchyma: significance for the regulation of glycogen metabolism, gluconeogenesis, and glycolysis. Diabetes Metab Rev. 1987 Jan;3(1):269–293. doi: 10.1002/dmr.5610030112. [DOI] [PubMed] [Google Scholar]
  87. Kaplan M. M. Subcellular alterations causing reduced hepatic thyroxine-5'-monodeiodinase activity in fasted fats. Endocrinology. 1979 Jan;104(1):58–64. doi: 10.1210/endo-104-1-58. [DOI] [PubMed] [Google Scholar]
  88. Kaplan M. M., Utiger R. D. Iodothyronine metabolism in rat liver homogenates. J Clin Invest. 1978 Feb;61(2):459–471. doi: 10.1172/JCI108957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Katz J., Golden S., Wals P. A. Glycogen synthesis by rat hepatocytes. Biochem J. 1979 May 15;180(2):389–402. doi: 10.1042/bj1800389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Kerbey A. L., Radcliffe P. M., Randle P. J. Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A. Biochem J. 1977 Jun 15;164(3):509–519. doi: 10.1042/bj1640509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Kerbey A. L., Randle P. J. Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation. Biochem J. 1982 Jul 15;206(1):103–111. doi: 10.1042/bj2060103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  92. Kreutner W., Springer S. C., Sherwood J. E. Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice. Am J Physiol. 1975 Feb;228(2):663–671. doi: 10.1152/ajplegacy.1975.228.2.663. [DOI] [PubMed] [Google Scholar]
  93. Kuwajima M., Golden S., Katz J., Unger R. H., Foster D. W., McGarry J. D. Active hepatic glycogen synthesis from gluconeogenic precursors despite high tissue levels of fructose 2,6-bisphosphate. J Biol Chem. 1986 Feb 25;261(6):2632–2637. [PubMed] [Google Scholar]
  94. Kuwajima M., Newgard C. B., Foster D. W., McGarry J. D. The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis. J Biol Chem. 1986 Jul 5;261(19):8849–8853. [PubMed] [Google Scholar]
  95. Lamers W. H., Hanson R. W., Meisner H. M. cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei. Proc Natl Acad Sci U S A. 1982 Sep;79(17):5137–5141. doi: 10.1073/pnas.79.17.5137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. Landau B. R., Wahren J. Quantification of the pathways followed in hepatic glycogen formation from glucose. FASEB J. 1988 May;2(8):2368–2375. doi: 10.1096/fasebj.2.8.3282961. [DOI] [PubMed] [Google Scholar]
  97. Lang C. H., Bagby G. J., Blakesley H. L., Johnson J. L., Spitzer J. J. Plasma glucose concentration determines direct versus indirect liver glycogen synthesis. Am J Physiol. 1986 Nov;251(5 Pt 1):E584–E590. doi: 10.1152/ajpendo.1986.251.5.E584. [DOI] [PubMed] [Google Scholar]
  98. Lavoinne A., Baquet A., Hue L. Stimulation of glycogen synthesis and lipogenesis by glutamine in isolated rat hepatocytes. Biochem J. 1987 Dec 1;248(2):429–437. doi: 10.1042/bj2480429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  99. Linn T. C., Pettit F. H., Hucho F., Reed L. J. Alpha-keto acid dehydrogenase complexes. XI. Comparative studies of regulatory properties of the pyruvate dehydrogenase complexes from kidney, heart, and liver mitochondria. Proc Natl Acad Sci U S A. 1969 Sep;64(1):227–234. doi: 10.1073/pnas.64.1.227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Linn T. C., Pettit F. H., Reed L. J. Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation. Proc Natl Acad Sci U S A. 1969 Jan;62(1):234–241. doi: 10.1073/pnas.62.1.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  101. Malbon C. C., Campbell R. Thyroid hormone administration in vivo regulates the activity of hepatic glycogen phosphorylase phosphatase. Endocrinology. 1982 Dec;111(6):1791–1796. doi: 10.1210/endo-111-6-1791. [DOI] [PubMed] [Google Scholar]
  102. Malewiak M. I., Griglio S., Kalopissis A. D., Le Liepvre X. Oleate metabolism in isolated hepatocytes from lean and obese Zucker rats. Influence of a high fat diet and in vitro response to glucagon. Metabolism. 1983 Jul;32(7):661–668. doi: 10.1016/0026-0495(83)90121-x. [DOI] [PubMed] [Google Scholar]
  103. Marchington D. R., Kerbey A. L., Jones A. E., Randle P. J. Insulin reverses effects of starvation on the activity of pyruvate dehydrogenase kinase in cultured hepatocytes. Biochem J. 1987 Aug 15;246(1):233–236. doi: 10.1042/bj2460233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. McCormack J. G., Denton R. M. Evidence that fatty acid synthesis in the interscapular brown adipose tissue of cold-adapted rats is increased in vivo by insulin by mechanisms involving parallel activation of pyruvate dehydrogenase and acetyl-coenzyme A carboxylase. Biochem J. 1977 Sep 15;166(3):627–630. doi: 10.1042/bj1660627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. McCormack J. G. The regulation of fatty acid synthesis in brown adipose tissue by insulin. Prog Lipid Res. 1982;21(3):195–223. doi: 10.1016/0163-7827(82)90009-1. [DOI] [PubMed] [Google Scholar]
  106. McCune S. A., Durant P. J., Jenkins P. A., Harris R. A. Comparative studies on fatty acid synthesis, glycogen metabolism, and gluconeogenesis by hepatocytes isolated from lean and obese Zucker rats. Metabolism. 1981 Dec;30(12):1170–1178. doi: 10.1016/0026-0495(81)90037-8. [DOI] [PubMed] [Google Scholar]
  107. McGarry J. D., Foster D. W. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem. 1980;49:395–420. doi: 10.1146/annurev.bi.49.070180.002143. [DOI] [PubMed] [Google Scholar]
  108. McGarry J. D., Kuwajima M., Newgard C. B., Foster D. W., Katz J. From dietary glucose to liver glycogen: the full circle round. Annu Rev Nutr. 1987;7:51–73. doi: 10.1146/annurev.nu.07.070187.000411. [DOI] [PubMed] [Google Scholar]
  109. Minatogawa Y., Hue L. Fructose 2,6-bisphosphate in rat skeletal muscle during contraction. Biochem J. 1984 Oct 1;223(1):73–79. doi: 10.1042/bj2230073. [DOI] [PMC free article] [PubMed] [Google Scholar]
  110. Minderop R. H., Hoeppner W., Seitz H. J. Regulation of hepatic glucokinase gene expression. Role of carbohydrates, and glucocorticoid and thyroid hormones. Eur J Biochem. 1987 Apr 1;164(1):181–187. doi: 10.1111/j.1432-1033.1987.tb11009.x. [DOI] [PubMed] [Google Scholar]
  111. Munday M. R., Hardie D. G. The role of acetyl-CoA carboxylase phosphorylation in the control of mammary gland fatty acid synthesis during the starvation and re-feeding of lactating rats. Biochem J. 1986 Jul 1;237(1):85–91. doi: 10.1042/bj2370085. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Newgard C. B., Hirsch L. J., Foster D. W., McGarry J. D. Studies on the mechanism by which exogenous glucose is converted into liver glycogen in the rat. A direct or an indirect pathway? J Biol Chem. 1983 Jul 10;258(13):8046–8052. [PubMed] [Google Scholar]
  113. Newsholme E. A., Arch J. R., Brooks B., Surholt B. The role of substrate cycles in metabolic regulation. Biochem Soc Trans. 1983 Jan;11(1):52–56. doi: 10.1042/bst0110052. [DOI] [PubMed] [Google Scholar]
  114. Newsholme E. A., Crabtree B., Ardawi M. S. The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells. Biosci Rep. 1985 May;5(5):393–400. doi: 10.1007/BF01116556. [DOI] [PubMed] [Google Scholar]
  115. Niewoehner C. B., Gilboe D. P., Nuttall F. Q. Metabolic effects of oral glucose in the liver of fasted rats. Am J Physiol. 1984 Jan;246(1 Pt 1):E89–E94. doi: 10.1152/ajpendo.1984.246.1.E89. [DOI] [PubMed] [Google Scholar]
  116. Nishikori K., Iritani N., Numa S. Levels of acetyl coenzyme A carboxylase and its effectors in rat liver after short-term fat-free refeeding. FEBS Lett. 1973 May 15;32(1):19–21. doi: 10.1016/0014-5793(73)80725-2. [DOI] [PubMed] [Google Scholar]
  117. Olefsky J. M., Kolterman O. G., Scarlett J. A. Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am J Physiol. 1982 Jul;243(1):E15–E30. doi: 10.1152/ajpendo.1982.243.1.E15. [DOI] [PubMed] [Google Scholar]
  118. Pallardo F. V., Williamson D. H. Comparison of the flux of carbon to hepatic glycogen deposition and fatty acid and cholesterol synthesis on refeeding rats fed ad libitum or meal-fed rats with a chow-diet meal. Biochem J. 1989 Jan 15;257(2):607–610. doi: 10.1042/bj2570607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. Palmer T. N., Caldecourt M. A., Snell K., Sugden M. C. Alanine and inter-organ relationships in branched-chain amino and 2-oxo acid metabolism. Review. Biosci Rep. 1985 Dec;5(12):1015–1033. doi: 10.1007/BF01119623. [DOI] [PubMed] [Google Scholar]
  120. Picton C., Woodgett J., Hemmings B., Cohen P. Multisite phosphorylation of glycogen synthase from rabbit skeletal muscle. Phosphorylation of site 5 by glycogen synthase kinase-5 (casein kinase-II) is a prerequisite for phosphorylation of sites 3 by glycogen synthase kinase-3. FEBS Lett. 1982 Dec 13;150(1):191–196. doi: 10.1016/0014-5793(82)81332-x. [DOI] [PubMed] [Google Scholar]
  121. Pilkis S. J., el-Maghrabi M. R., Claus T. H. Hormonal regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Biochem. 1988;57:755–783. doi: 10.1146/annurev.bi.57.070188.003543. [DOI] [PubMed] [Google Scholar]
  122. Pénicaud L., Ferré P., Kande J., Leturque A., Issad T., Girard J. Effect of anesthesia on glucose production and utilization in rats. Am J Physiol. 1987 Mar;252(3 Pt 1):E365–E369. doi: 10.1152/ajpendo.1987.252.3.E365. [DOI] [PubMed] [Google Scholar]
  123. Pénicaud L., Ferré P., Terretaz J., Kinebanyan M. F., Leturque A., Doré E., Girard J., Jeanrenaud B., Picon L. Development of obesity in Zucker rats. Early insulin resistance in muscles but normal sensitivity in white adipose tissue. Diabetes. 1987 May;36(5):626–631. doi: 10.2337/diab.36.5.626. [DOI] [PubMed] [Google Scholar]
  124. Rafael J., Hüsch M., Stratmann D., Hohorst H. J. Mitochondrien aus braunem und weissem Fettgewebe: Struktur, Enzymprofil und oxidative Phosphorylierung. Hoppe Seylers Z Physiol Chem. 1970 Dec;351(12):1513–1523. [PubMed] [Google Scholar]
  125. Rafael J., Klaas D., Hohorst H. J. Mitochondrien aus braunem Fettgewebe: Enzyme und atmungskettenphosphorylierung während der prä- und postnatalen Entwicklung des interscapularen Fettkörpers des Meerschweinchesn. Hoppe Seylers Z Physiol Chem. 1968 Dec;349(12):1711–1724. [PubMed] [Google Scholar]
  126. Randle P. J. Fuel selection in animals. Biochem Soc Trans. 1986 Oct;14(5):799–806. doi: 10.1042/bst0140799. [DOI] [PubMed] [Google Scholar]
  127. Randle P. J., Newsholme E. A., Garland P. B. Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J. 1964 Dec;93(3):652–665. doi: 10.1042/bj0930652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Reaven G. M. Insulin resistance in noninsulin-dependent diabetes mellitus. Does it exist and can it be measured? Am J Med. 1983 Jan 17;74(1A):3–17. doi: 10.1016/0002-9343(83)90650-2. [DOI] [PubMed] [Google Scholar]
  129. Rennie M. J., Hundal H. S., Babij P., MacLennan P., Taylor P. M., Watt P. W., Jepson M. M., Millward D. J. Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease. Lancet. 1986 Nov 1;2(8514):1008–1012. doi: 10.1016/s0140-6736(86)92617-6. [DOI] [PubMed] [Google Scholar]
  130. Rider M. H. Regulation of fructose-2,6-bisphosphate synthesis and breakdown in heart and skeletal muscle. Biochem Soc Trans. 1987 Oct;15(5):988–991. doi: 10.1042/bst0150988. [DOI] [PubMed] [Google Scholar]
  131. Rohner-Jeanrenaud F., Proietto J., Ionescu E., Jeanrenaud B. Mechanism of abnormal oral glucose tolerance of genetically obese fa/fa rats. Diabetes. 1986 Dec;35(12):1350–1355. doi: 10.2337/diab.35.12.1350. [DOI] [PubMed] [Google Scholar]
  132. Schofield P. S., Sugden M. C., Corstorphine C. G., Zammit V. A. Altered interactions between lipogenesis and fatty acid oxidation in regenerating rat liver. Biochem J. 1987 Jan 15;241(2):469–474. doi: 10.1042/bj2410469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Shikama H., Ui M. Glucose load diverts hepatic gluconeogenic product from glucose to glycogen in vivo. Am J Physiol. 1978 Oct;235(4):E354–E360. doi: 10.1152/ajpendo.1978.235.4.E354. [DOI] [PubMed] [Google Scholar]
  134. Souba W. W., Smith R. J., Wilmore D. W. Glutamine metabolism by the intestinal tract. JPEN J Parenter Enteral Nutr. 1985 Sep-Oct;9(5):608–617. doi: 10.1177/0148607185009005608. [DOI] [PubMed] [Google Scholar]
  135. Stalmans W., Bollen M., Mvumbi L. Control of glycogen synthesis in health and disease. Diabetes Metab Rev. 1987 Jan;3(1):127–161. doi: 10.1002/dmr.5610030107. [DOI] [PubMed] [Google Scholar]
  136. Stalmans W., De Wulf H., Hue L., Hers H. G. The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose. Eur J Biochem. 1974 Jan 3;41(1):127–134. doi: 10.1111/j.1432-1033.1974.tb03252.x. [DOI] [PubMed] [Google Scholar]
  137. Stansbie D., Brownsey R. W., Crettaz M., Denton R. M. Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats. Biochem J. 1976 Nov 15;160(2):413–416. doi: 10.1042/bj1600413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Steiner D. F. Insulin and the regulation of hepatic biosynthetic activity. Vitam Horm. 1966;24:1–61. doi: 10.1016/s0083-6729(08)60202-2. [DOI] [PubMed] [Google Scholar]
  139. Storlien L. H., James D. E., Burleigh K. M., Chisholm D. J., Kraegen E. W. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol. 1986 Nov;251(5 Pt 1):E576–E583. doi: 10.1152/ajpendo.1986.251.5.E576. [DOI] [PubMed] [Google Scholar]
  140. Storlien L. H., Kraegen E. W., Chisholm D. J., Ford G. L., Bruce D. G., Pascoe W. S. Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science. 1987 Aug 21;237(4817):885–888. doi: 10.1126/science.3303333. [DOI] [PubMed] [Google Scholar]
  141. Sugden M. C., Sharples S. C., Randle P. J. Carcass glycogen as a potential source of glucose during short-term starvation. Biochem J. 1976 Dec 15;160(3):817–819. doi: 10.1042/bj1600817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  142. Sugden M. C., Watts D. I., Marshall C. E., McCormack J. G. Brown-adipose-tissue lipogenesis in starvation: effects of insulin and (-) hydroxycitrate. Biosci Rep. 1982 May;2(5):289–297. doi: 10.1007/BF01115114. [DOI] [PubMed] [Google Scholar]
  143. Sugden M. C., Watts D. I., Palmer T. N., Myles D. D. Direction of carbon flux in starvation and after refeeding: in vitro and in vivo effects of 3-mercaptopicolinate. Biochem Int. 1983 Sep;7(3):329–337. [PubMed] [Google Scholar]
  144. Sugden P. H., Hutson N. J., Kerbey A. L., Randle P. J. Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase. Biochem J. 1978 Feb 1;169(2):433–435. doi: 10.1042/bj1690433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  145. Tao T. Y., Towle H. C. Coordinate regulation of rat liver genes by thyroid hormone and dietary carbohydrate. Ann N Y Acad Sci. 1986;478:20–30. doi: 10.1111/j.1749-6632.1986.tb15518.x. [DOI] [PubMed] [Google Scholar]
  146. Terjung R. L., Baldwin K. M., Winder W. W., Holloszy J. O. Glycogen repletion in different types of muscle and in liver after exhausting exercise. Am J Physiol. 1974 Jun;226(6):1387–1391. doi: 10.1152/ajplegacy.1974.226.6.1387. [DOI] [PubMed] [Google Scholar]
  147. Terrettaz J., Assimacopoulos-Jeannet F., Jeanrenaud B. Inhibition of hepatic glucose production by insulin in vivo in rats: contribution of glycolysis. Am J Physiol. 1986 Apr;250(4 Pt 1):E346–E351. doi: 10.1152/ajpendo.1986.250.4.E346. [DOI] [PubMed] [Google Scholar]
  148. Thomas A. P., Diggle T. A., Denton R. M. Sensitivity of pyruvate dehydrogenase phosphate phosphatase to magnesium ions. Similar effects of spermine and insulin. Biochem J. 1986 Aug 15;238(1):83–91. doi: 10.1042/bj2380083. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Tóth B., Bollen M., Stalmans W. Acute regulation of hepatic protein phosphatases by glucagon, insulin, and glucose. J Biol Chem. 1988 Oct 5;263(28):14061–14066. [PubMed] [Google Scholar]
  150. Van de Werve G., Jeanrenaud B. Synthase activation is not a prerequisite for glycogen synthesis in the starved liver. Am J Physiol. 1984 Aug;247(2 Pt 1):E271–E275. doi: 10.1152/ajpendo.1984.247.2.E271. [DOI] [PubMed] [Google Scholar]
  151. Van de Werve G., Sestoft L., Folke M., Kristensen L. O. The onset of liver glycogen synthesis in fasted-refed rats. Effects of streptozocin diabetes and of peripheral insulin replacement. Diabetes. 1984 Oct;33(10):944–949. [PubMed] [Google Scholar]
  152. Watts C., Redshaw J. R., Gain K. R. The activation of glycogen synthase in hepatocytes from rats with a glycogen storage disorder (gsd/gsd). FEBS Lett. 1982 Aug 2;144(2):231–234. doi: 10.1016/0014-5793(82)80644-3. [DOI] [PubMed] [Google Scholar]
  153. Wieland O. H. The mammalian pyruvate dehydrogenase complex: structure and regulation. Rev Physiol Biochem Pharmacol. 1983;96:123–170. doi: 10.1007/BFb0031008. [DOI] [PubMed] [Google Scholar]
  154. de Wulf H., Hers H. G. The interconversion of liver glycogen synthetase a and b in vitro. Eur J Biochem. 1968 Dec 5;6(4):552–557. doi: 10.1111/j.1432-1033.1968.tb00480.x. [DOI] [PubMed] [Google Scholar]

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