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. 2024 Aug 9;17:65. doi: 10.1186/s13045-024-01578-x

Table 8.

Summary of under-investigation novel immunotherapies involving GI tract cancers

Strategy Category Target Regimen Status Sample size(estimated) NCT number
Cell therapy CAR-T cells CLDN18.2 AZD6422 Recruiting 96 NCT05981235
EpCAM EPCAM CAR-T cells Recruiting 48 NCT05028933
GCC IM96 CAR-T cells Recruiting 19 NCT05287165
GCC LCAR-G08 cells Recruiting 42 NCT06197178
CEA CEA CAR-T cells Recruiting 36 NCT06010862
LGR5 LGR5-targeted CAR-T Cells Recruiting 45 NCT05759728
MSLN αPD-1-MSLN-CAR T Cells Recruiting 30 NCT05089266
B7-H3 anti-CD276 CAR T cells Recruiting 100 NCT04432649
CAR-T/TCR-T cells NY-ESO-1, DR5, EGFR vIII, Mesothelin CAR-T/TCR-T cells unknown 50 NCT03941626
Muti-targets Cyclophosphamide/Fludarabine + CAR-T/TCR-T cells unknown 73 NCT03638206
TCR-T cells NY-ESO-1 TBI-1301 + Cyclophosphamide/TBI-1301 + Cyclophosphamide + Fludarabine unknown 9 NCT02366546
PRAME IMA203/IMA203CD8 product Recruiting 186 NCT03686124
CAR-NK92 cells NKG2D NKG2D-CAR-NK92 cells Recruiting 20 NCT05528341
CAR-macrophage cells HER-2 HER-2-targeted CAR-M cell Not yet recurting 9 NCT06224738
Tumour vaccine mRNA vaccine Personalized Neoantigen Neoantigen tumor vaccine with or without PD-1/L1 Recruiting 30 NCT05192460
Personalized Neoantigen SW1115C3 Recruiting 30 NCT05198752
Personalized Neoantigen RO7198457 Recruiting 229 NCT04486378
Personalized Neoantigen Cyclophosphamide + personalized neoantigen vaccine + Pembrolizumab Recruiting 36 NCT05269381
Dendritic Cell Vaccine Neoantigen Neoantigen DC Vaccine and Nivolumab Recruiting 60 NCT04912765
ICIs Beyond PD-1/L1 ICIs Beyond PD-1/L1 TIGIT A: Tislelizumab plus Ociperlimab B: Tislelizumab plus Placebo Completed 125 (actual) NCT04732494
TIGIT Pembrolizumab/Vibostolimab Recruiting 610 NCT05007106
TIGIT BAT6005 Recruiting 36 NCT05116709
LAG3 BMS-986213 + chemotherapy Completed 274 (actual) NCT03662659
LAG3 IBI 110 ± sintilimab Recruiting 268 NCT04085185
CTLA-4 Pembrolizumab/Quavonlimab Recruiting 320 NCT04895722
MICA/B CLN619 + Pembrolizumab Recruiting 410 NCT05117476
Oncolytic viruses Oncolytic viruses Oncolytic virus IDOV-SAFE Recruiting 60 NCT06380309
Oncolytic virus HX008 Recruiting 300 NCT03866525
Oncolytic virus R130 Recruiting 20 NCT05961111
Oncolytic virus T3011 Recruiting 233 NCT05602792