FIG. 6.
Histology and immunostaining of brain sections from an MxA+/+ IFNAR-1−/− mouse and an MxA−/− IFNAR-1−/− mouse. Both were infected with 100 PFU of SFV per ml by the intraperitoneal route. Mice were sacrificed 4 days after infection, and brain sections were prepared. Micrographs show the brain of an MxA+/+ IFNAR-1−/− mouse (panels A to D) and that of an MxA−/− IFNAR-1−/− mouse (panels E to H) immunostained for MxA protein (panels A and E), the C protein of SFV (panels B and F), or GFAP (panels D and H) or stained with hematoxylin and eosin (HE) (panels C and G).