FIG. 3.
Enhanced resistance of MxA-transgenic IFNAR-1−/− mice to LACV infection. (A) Adult MxA+/+ IFNAR-1−/− (■) and MxA−/− IFNAR-1−/− (□) mice were infected with 105 TCID50 of LACV by the intraperitoneal route and monitored for survival. (B) Virus growth in brains of susceptible and resistant mice. Two MxA+/+ IFNAR-1−/− mice (animals 1 and 2) and three MxA−/− IFNAR-1−/− mice (animals 3, 4, and 5) were infected as described above and sacrificed 6 days after infection. Tissue samples were removed and assayed for infectivity.