Table 2.
Comparison of frequencies of HLA genotypes between controls and each patient groups
| HLA genotypesa | CD-T1D (n = 76) | T1D (n = 1,064) | CD (n = 746) | Controls (n = 627) | |
| DQ2.5/DQ8 | No. (%) | 30 (39.5) | 316 (29.7) | 57 (7.6) | 21 (3.3) |
| P value | 2 × 10−30 | 3.2 × 10−39 | 6.2 × 10−4 | / | |
| OR (CI) | 18.8 (10–35.4) | 12.2 (7.7–19.2) | 2.4 (1.4–4) | / | |
| DQ2.5/DQ2.5 | No. (%) | 29 (38.2) | 329 (30.9) | 153 (20.5) | 33 (5.3) |
| P value | 1.3 × 10−21 | 1.9 × 10−35 | 2 × 10−16 | / | |
| OR (CI) | 11.1 (6.2–19.8) | 8.1 (5.5–11.7) | 4.6 (3.1–6.9) | / | |
| DQ2.5/DQ2.3 | No. (%) | 3 (3.9) | 26 (2.4) | 13 (1.7) | 4 (0.6) |
| P value | 1.6 × 10−2 | 1.2 × 10−2 | Ns | / | |
| OR (CI) | 6.4 (1.4–29.1) | 3.9 (1.4–11.2) | — | / | |
| DQ8/DQ8 | No. (%) | 1 (1.3) | 24 (2.3) | 10 (1.3) | 2 (0.3) |
| P value | ns | 9 × 10−4 | Ns | / | |
| OR (CI) | / | 7.2 (1.7–30.6) | — | / | |
| DQ2.5/DQ2.2 | No. (%) | 0 | 14 (1.3) | 111 (14.9) | 17 (2.7) |
| P value | ns | 3.9 × 10−2 | 1.1 × 10−14 | / | |
| OR (CI) | / | 0.5 (0.2–1) | 6.3 (3.7–10.6) | / | |
| DQ7/DQ2.2 or DQ7/DQ2.3 | No. (%) | 0 | 2 (0.2) | 41 (5.5) | 20 (3.2) |
| P value | ns | 1 × 10−4 | 3.9 × 10−2 | / | |
| OR (CI) | / | 0.1 (0.1–0.2) | 1.8 (1–3) | / | |
| DQ2.5/x | No. (%) | 6 (7.9) | 208 (19.5) | 271 (36.3) | 165 (26.3) |
| P value | 2 × 10−2 | 1.2 × 10−3 | 7.2 × 10−5 | / | |
| OR (CI) | 0.2 (0.1–0.6) | 0.1 (0.5–0.9) | 1.6 (1.3–2.) | / | |
| DQ2.2/x | No. (%) | 0 | 4 (0.4) | 17 (2.3) | 28 (4.5) |
| P value | ns | 1 × 10−4 | 2.3 × 10−2 | / | |
| OR (CI) | / | 0.1 (0.1–0.2) | 0.5 (0.3–0.9) | / | |
| DQ8/x | No. (%) | 2 (2.6) | 48 (4.5) | 15 (2) | 38 (6.1) |
| P value | ns | ns | 1 × 10−4 | / | |
| OR (CI) | — | — | 0.3 (0.2–0.6) | / | |
| Others | No. (%) | 5 (6.6) | 93 (8.7) | 74 (9.9) | 299 (47.7) |
| P value | 9.1 × 10−12 | 4.6 × 10−75 | 1.7 × 10−52 | / | |
| OR (CI) | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) | 0.1 (0.1–0.2) | / |
CD-T1D, celiac disease type 1 diabetes; CI, confidence interval; HLA, human leukocyte antigen; OR, odds ratio.
a
The HLA genotypes analyzed are those that confer greater susceptibility for CD or T1D.