Figure 2.
Classification evaluation of each single ROI’s HDAC enzyme distribution density
(A) Radar plot and (B) bar chart showing the F1 score classification metric of individual brain ROIs SUVR feature in differentiating AUD vs. CNT using SVM machine learning classification algorithm. In the radar plot, the blue curve indicates the F1 score of the [11C]Martinostat SUVRWB feature of the 100 brain regions, whereas the orange curve shows the F1 score metric of the [11C]Martinostat SUVRPONS features. The following regions’ SUVRWB features demonstrate a relatively higher F1 score in the classification process: V_35 (left-caudal middle frontal cortex) = 73%, V_61 (left-superior temporal cortex) = 71%, V_51 (left-parstriangularis cortex) = 70%, and V_77 (right-lateral orbitofrontal cortex) = 70%.