FIG. 5.
Adenovirus infection produced a decline in viral core antigen in the liver. Immunoperoxidase staining of fixed liver tissue for detection of viral core (nucleocapsid) antigen was carried out as described in Materials and Methods. Two biopsies are illustrated, one collected 1 month before adenovirus or mock infection the other collected 15 days after. The major effect noticed for woodchuck 326 was a decline in the number of hepatocytes with a strong staining reaction. A lesser decline was observed with woodchuck 328 (not shown). No appreciable decline was observed in woodchucks 331 and 338 or in any of the mock-infected controls (for example, 336 shown here). Magnification, ×200.