FIG. 7.
Donor-dependent variation in the effects of coreceptor-targeted inhibitors in PBMC. (a) SIVmac239 replication in PBMC from four different macaques was evaluated in the presence of TAK-779 at 33 μM, 3.3 μM, 330 nM, and 33 nM. SIVmac251 was similarly evaluated with cells from two donors. (b) HIV-1 P6-v3 replication in PBMC from four different human donors was evaluated in the presence of TAK-779 at 3.3 μM, 330 nM, 33 nM, and 3 nM. In each case, replication was measured after 7 and 10 days, and IC50s of the inhibitor were calculated. The data shown were obtained on day 10, but values from day 7 were similar.