FIG. 5.
Effects of coreceptor-targeted inhibitors on HIV-2 isolate 7924A in PBMC from different donors. The replication of HIV-2 7924A in PBMC from four different human donors in the presence of AMD3100 at 40 μM, 4 μM, 400 nM, and 40 nM (a) and SDF-1α at 400 nM, 40 nM, 4 nM, and 0.4 nM (b) was evaluated. HIV-1 NL4-3 was also tested with SDF-1α. In each case, replication was measured after 7 and 10 days. IC50s of AMD3100 were calculated and are shown in panel a. The data shown were obtained on day 10, but values from day 7 were similar.