Table 2.
Summary data of Treg clusters induced by tolerogenic dendritic cells (tolDCs) against proinsulin peptide.
| Cluster 1 | Cluster 2 | Cluster 3 | |
|---|---|---|---|
| Mechanism of priming | iTregs primed by tolDCs |
iTregs primed by tolDCs |
iTregs primed by tolDCs |
| Function | Monocyte killing Inhibition of naïve T cells and Th1 responses |
Monocyte killing | Monocyte killing Strong inhibition of naïve T cells and Th1 responses |
| Expression of markers | High amounts of IL-10, TNF, IFN-γ, and IL-13 CTLA4 Granzyme B |
Granzyme B | CTLA4 Some make IL-10 |
| Peculiarity | Reversed TCR docking | Infectious tolerance |