FIG. 3.
Sint1 maps in the distal region of mouse chromosome 11. Sint1 was placed on mouse chromosome 11 by interspecific backcross analysis. The segregation patterns of Sint1 and flanking genes in 108 backcross animals that were typed for all loci are shown at the top. For individual pairs of loci, more than 108 animals were typed (see text). Each column represents the chromosome identified in the backcross progeny that was inherited from the (C57BL/6J × M. spretus)F1 parent. Black, boxes, presence of a C57BL/6J allele; white boxes, presence of an M. spretus allele. The number of offspring inheriting each type of chromosome is listed at the bottom of each column. A partial chromosome 11 linkage map showing the location of Sint1 in relation to linked genes is shown at the bottom. Recombination distances between loci in centimorgans are shown to the left of the chromosome, and the positions of loci in human chromosomes, where known, are shown to the right. References for the human map positions of loci cited in this study can be obtained from the Genome Data Base, a computerized database of human linkage information maintained by the William H. Welch Medical Library of Johns Hopkins University (Baltimore, Md.).