Table 1.
Tumorigenicity of cancer cells
| Cell line | Number of cancer cells | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intraperitoneal inoculation | Subcutaneous inoculation | |||||||||
| 5 × 105 | 1 × 106 | 5 × 106 | 2 × 107 | 5 × 107 | 1 × 104 | 5 × 104 | 1 × 105 | 1 × 106 | 5 × 106 | |
| OCUM‐2M | 0/6 † | 0/14 | 0/16 | 0/10 | 0/4 | 0/4 | 0/6 | 0/9 | 2/10 | 3/14 |
| OCUM‐2M/SP | 1/5 | 2/5 | 5/5** | ND ‡ | ND | 0/5 | 4/5* | ND | ND | ND |
| OCUM‐2MD3 | 0/5 | 2/8 | 11/11** | 4/4 | 4/4 | ND | ND | ND | ND | ND |
| OCUM‐2D | ND | 0/10 | 0/10 | ND | ND | ND | ND | 0/8 | 3/8 | 10/10 |
| OCUM‐2D/SP | ND | 0/4 | 3/4** | ND | ND | ND | ND | 3/11 | 8/8** | ND |
The tumor growth was determined at 8 weeks after inoculation.
†
Number of mice bearing a tumor/total number of mice.
‡
ND, not determined.
*
P < 0.05; versus OCUM‐2M or OCUM‐2D.
**
P < 0.01; versus OCUM‐2M or OCUM‐2D.