Table 3.
Univariate and multivariate Cox regression analysis of potential prognostic factors for DFS
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Number | Median survival (months) | P‐value | HR | 95% CI | P‐value | |
| UICC stage | ||||||
| I, II | 29 | 21.6 | 0.1003 | |||
| III, IV | 10 | 9.9 | ||||
| Tumor size (cm) | ||||||
| <4 | 18 | 18.9 | 0.0649 | 2.048 | 0.862–5.077 | 0.1218 |
| ≥4 | 21 | 10.9 | ||||
| Histologic differentiation | ||||||
| Well–Mod. | 30 | 18.1 | 0.8534 | |||
| Poor | 9 | 19.8 | ||||
| Lymph node metastasis | ||||||
| + | 12 | 9.7 | 0.0219 | 2.44 | 0.335–2.213 | 0.0269 |
| − | 27 | 29.8 | ||||
| CD68 | ||||||
| High | 19 | 16.3 | 0.0623 | |||
| Low | 20 | 18.3 | ||||
| CD163 | ||||||
| High | 20 | 11.2 | 0.0369 | 2.48 | 1.031–5.983 | 0.0426 |
| Low | 19 | 23.7 | ||||
| FOXP3 | ||||||
| High | 20 | 10.4 | 0.0999 | 1.003 | 0.244–4.129 | 0.9964 |
| Low | 19 | 20.3 | ||||
CI, confidence interval; DFS, disease free survival; FOXP3, forkhead box P3; HR, hazard ratio; UICC, International Union Against Cancer.