Figure 2.
Tumor growth after subcutaneous or intrahepatic implantation of MC38/mock and MC38/interleukin (IL)‐2 cells in mice treated with anti‐CD25 monoclonal antibody. (a) MC38/mock or MC38/IL‐2 cells (5 × 106 cells) were implanted subcutaneously, and the area of each tumor was calculated every other day. PC61 and phosphate‐buffered saline (PBS) were administered every 3 days beginning 6 days before implantation. Values for individual mice are shown (n = 5 in each group). Similar results were obtained in two independent experiments. (b) MC38/IL‐2 cells (1 × 106 cells) were implanted intrahepatically, and PC61 and PBS were administered as in (a). On days 7, 11, 14, 21 and 28 after implantation, the area of each tumor was calculated. The mean ± SD is shown (n = 10 in each experiment). *P < 0.05.