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Scheme for vanadate inhibition of the MalFGK2 transport complex. This scheme, describing the inhibition of ATP hydrolysis by vanadate (Vi), has been adapted from other work (15, 29, 36) and is modified to contain both high-energy (∗) and low-energy ADP-bound species. In this scheme, step 4, conversion from the high- to low-energy forms of the ADP-bound species, and step 6, formation of the *MalFGK2 · MgADP · Vi complex, are not readily reversible, as indicated by the dashed arrows.
