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. 2024 Apr 30;56(5):778–791. doi: 10.1038/s41588-024-01714-w

Table 3.

31 of the 113 novel loci (P < 5 × 10−8) identified with PP as the primary trait

SNP CHR:BP Trait Gene A1 A2 EAF Effect s.e. P value neff Phet
rs34361301 9:14535119 PP NFIB C T 0.266 0.122 0.02 6.76 × 10−10 974,146 0.322
rs34139656 16:88534923 PP ZFPM1 G A 0.327 −0.117 0.019 7.30 × 10−10 939,836 0.819
rs300753 2:209622 PP SH3YL1 T C 0.548 0.106 0.017 1.06 × 10−9 975,060 0.487
rs61241090 9:35191014 PP UNC13B C T 0.236 −0.123 0.02 1.40 × 10−9 991,997 0.658
rs116643984 15:101791212 PP CHSY1 A C 0.163 −0.143 0.024 2.45 × 10−9 954,926 0.806
rs2987903 9:133711263 PP ABL1 A G 0.128 −0.154 0.026 2.49 × 10−9 995,802 0.631
rs4944038 11:73783478 PP C2CD3 T A 0.477 −0.101 0.017 4.30 × 10−9 1,006,450 0.33
rs3821817 3:187456904 PP BCL6 G C 0.178 −0.135 0.023 4.59 × 10−9 944,591 0.274
rs77759442 11:110657616 PP ARHGAP20 T C 0.132 0.15 0.026 5.91 × 10−9 960,047 0.358
rs75177877 7:16117030 PP CRPPA T C 0.172 0.136 0.024 7.02 × 10−9 941,294 0.169
rs62253186 3:69919744 PP MITF G C 0.061 0.217 0.038 7.14 × 10−9 920,630 0.94
rs4517643 13:94417873 PP GPC6 C A 0.566 0.101 0.018 7.47 × 10−9 990,764 0.633
rs12828693 12:46385848 PP SCAF11 T C 0.205 0.125 0.022 8.20 × 10−9 970,335 0.806
rs4053778 6:85988429 PP LINC02535 G A 0.395 −0.103 0.018 8.67 × 10−9 968,001 0.332
rs71664847 1:115019239 PP TRIM33 T A 0.19 0.126 0.022 9.99 × 10−9 993,341 0.633
rs12134085 1:40763095 PP COL9A2 T C 0.198 −0.133 0.023 1.05 × 10−8 864,823 0.003
rs9320778 6:121258543 PP TBC1D32 T C 0.75 0.115 0.02 1.05 × 10−8 973,244 0.75
rs112324977 9:80751434 PP CEP78 A T 0.131 −0.147 0.026 1.07 × 10−8 992,833 0.763
rs72751391 9:122890934 PP MIR147A T C 0.125 0.156 0.027 1.23 × 10−8 907,738 0.942
rs10208493 2:196590414 PP SLC39A10 T C 0.571 −0.099 0.017 1.36 × 10−8 986,727 0.186
rs2953937 8:34164285 PP LINC01288 C A 0.133 0.143 0.026 1.76 × 10−8 993,180 0.135
rs36036692 8:108319395 PP ANGPT1 G C 0.374 0.1 0.018 1.89 × 10−8 997,711 0.167
rs12943001 17:78238645 PP RNF213 C T 0.641 −0.111 0.02 2.29 × 10−8 830,757 0.064
rs67615620 7:15421023 PP AGMO C T 0.199 0.122 0.022 2.32 × 10−8 973,513 0.463
rs9554446 13:98859019 PP FARP1 A T 0.095 0.166 0.03 2.32 × 10−8 974,068 0.586
rs9671694 14:103330144 PP TRAF3 G C 0.337 0.104 0.019 2.40 × 10−8 961,925 0.743
rs72943226 6:99548729 PP MIR548AI A G 0.319 0.102 0.018 3.12 × 10−8 999,371 0.245
rs1062298 12:12045264 PP ETV6 T G 0.421 0.097 0.018 3.24 × 10−8 977,558 0.084
rs855791 22:37462936 PP TMPRSS6 G A 0.563 −0.096 0.017 3.24 × 10−8 996,826 0.861
rs12084868 1:72229240 PP NEGR1 A G 0.028 0.302 0.055 4.67 × 10−8 898,662 0.546
rs11022023 11:11793978 PP MIR8070 A G 0.083 −0.174 0.032 4.80 × 10−8 964,778 0.539

31 of the 113 novel loci (P < 5 × 10−8) with concordant direction of effect in all available studies after distance-based (±500 kb) and LD (r2 > 0.1) pruning, identified with PP as the primary trait. SNPs are ordered by two-sided P value for the most significant BP association in inverse variance-weighted meta-analyses. SNP, dbSNP accession number; CHR:BP, chromosome and build 37 position; Trait, primary BP trait for which the most significant association was observed and for which summary statistics are provided in subsequent columns; for novel loci which reach genome-wide significance (P < 5 × 10−8) for a second trait, this second trait is also listed; Nearest Gene, most proximal gene within 250 kb of sentinel SNP; A1, allele corresponding to measured effect on the outcome; A2, allele not corresponding to measured effect on the outcome; EAF, effect allele frequency in the meta-analysis; Effect, measured effect in the meta-analysis (mmHg); s.e., standard error of the measured effect in the meta-analysis; P value, association P value for the measured effect in the meta-analysis; neff, effective number of subjects in the GWAS meta-analysis (calculated at study-level as n × SNP imputation quality INFO); Phet, value for Cochran’s Q test of statistical heterogeneity in the GWAS meta-analysis.