Fig. 2.
IFN-α transduction of MC38 tumor cells suppresses the growth of wild-type tumor established in the contralateral flank. Animals were inoculated with MC38-WT (1×105 cells) in the right flank on day 0. On day 7, established MC38 (16–30 mm2 in size) were treated three times, with Neo-, IFN-α-, or IL-12-expressing MC38 cells (105 cells), in the contralateral (left) flank, every third day starting 7 days after wild-type tumor injection. Six mice were studied in each group. Results are reported as mean tumor area (square millimeters) plus standard error. Significance at 95% confidence limits is indicated. This experiment was performed twice with similar results